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Details for anatomical structure: acidophil mammotroph cell of anterior pituitary

EndoNet ID: ENC00001

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Synonyms

acidophil mammotroph cell of anterior pituitary, chromophil cell, Endocrinocytus acidophilus

General information

secreting prolactin

Links to other resources

Cytomer cy0011196

Larger structures

    Substructures

      Secreted hormones

      • Hormone: angiotensin II

        • Nonclassical Anterior Pituitary Substances:Peptides [1]
      • Hormone: galanin

        • Nonclassical Anterior Pituitary Substances:Peptides [1]
      • Hormone: TRH

        • Nonclassical Anterior Pituitary Substances: Peptides [1]
      • Hormone: VIP

      • Hormone: PRL

        Influenced by:

        • dopamine receptor D2
          in acidophil_mammotroph_cell_of_anterior_pituitary
        • TRH-R
          in acidophil_mammotroph_cell_of_anterior_pituitary
        • CXCR1
          in acidophil_mammotroph_cell_of_anterior_pituitary
          • CINC/ stimulates PRL secretion from anterior pituitary monolayer cultures in a concentration-dependent manner with a substantioal lag time. [3]
        • GHS-R1
          in pituitary_gland_of_diencephalon
          • ...stimulatory effect of CST on PRL release is exerted through a receptor not shared by SST...it has been reported that CST(...)binds with high affinity to GHS-R1a(...) which in turn is known to stimulate PRL secretion [4]

      Receptors

      • Receptor: dopamine receptor D2

        Induced phenotype:

        • Hyperprolactinemia
          • Hyperprolactinaemia is common in patients with hypopituitarism, due to the interference of a pituitary mass with dopaminergic inhibition of prolactin secretion. [5]

        Influences:

        • PRL
      • Receptor: TRH-R

        Influences:

        • PRL
      • Receptor: CXCR1

        Influences:

        • PRL
          • CINC/ stimulates PRL secretion from anterior pituitary monolayer cultures in a concentration-dependent manner with a substantioal lag time. [3]
      Reference