Details for anatomical structure: acidophil somatotroph cell of anterior pituitary
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- General information
- Related structures
- Hormones
- Receptors
-
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- Top
- General information
- Related structures
- Hormones
- Receptors
-
Click to access the toolbox
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Synonyms
acidophil somatotroph cell of anterior pituitary, chromophil cell, Endocrinocytus acidophilusGeneral information
secreting growth hormone (HGH)Links to other resources
Cytomer | cy0011193 |
Related structures
Larger structures
Substructures
Secreted hormones
-
Hormone: angiotensin II
-
Hormone: galanin
-
Hormone: motilin
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Hormone: TRH
-
Hormone: IGF-1
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Hormone: GH
- GH secretion is regulated by indirect negative feedback mechanisms via autocrine actions of GH at the pituitary. [2]
Influenced by:
- sst5 in acidophil_somatotroph_cell_of_anterior_pituitary
- GHS-R1 in acidophil_somatotroph_cell_of_anterior_pituitary
- GHRH-R in acidophil_somatotroph_cell_of_anterior_pituitary
- IGF-1R in acidophil_somatotroph_cell_of_anterior_pituitary
- sst2 in acidophil_somatotroph_cell_of_anterior_pituitary
- CXCR1
in
acidophil_somatotroph_cell_of_anterior_pituitary
- CINC/gro stiumaletes GH secretion from anterior pituitary monolayer cultures in a concentration-dependent manner with a substantial lag time. [6]
- leptin receptor
in
acidophil_somatotroph_cell_of_anterior_pituitary
- Leptin-deficient patients although exhibited normal height, presented decreased GH response to ITT and physical exercise, whereas leptin-resitant patients subjects have significant growth delay during early childhood and decreased GH secretion. [7]
- GHS-R1
in
hypothalamus
- GHS-R 1a mediates the classical GH-releasing effect [8]
Receptors
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Receptor: GHS-R1
Influences:
-
Receptor: GHRH-R
Induced phenotype:
- Growth hormone deficiency
- One cause of growth hormone deficiency is a mutation in the GHRH-R gene. [9]
- dwarfism
Influences:
- Growth hormone deficiency
-
Receptor: sst2
Influences:
-
Receptor: sst5
Influences:
-
Receptor: leptin receptor
Influences:
-
Receptor: IGF-1R
Induced phenotype:
- cell growth
- Insulin-like growth factor-1 mediates regulatory effects on cell growth by activation of IGF-1 receptor. [10]
- positive regulation of cell proliferation
- Insulin-like growth factor-1 stimulates proliferation of cells , required for sustained growth of many cells. [11]
- negative regulation of apoptosis
- Insulin-like growth factor-1 protects cells from apoptosis. [12]
- transformation
- Insulin-like growth factor-1 is required for transformation and maintenance of transformed state. [13]
Influences:
- cell growth
-
Receptor: orexin receptor 1
-
Receptor: CXCR1
Influences: