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Details for anatomical structure: basophil gonadotroph cell of anterior pituitary FSH

EndoNet ID: ENC00003

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Synonyms

basophil gonadotroph cell of anterior pituitary FSH, chromophil cell, Endocrinocytus basophilus

General information

secreting follicle-stimulating hormone

Links to other resources

Cytomer cy0011194

Larger structures

    Substructures

      Secreted hormones

      • Hormone: LH

        Influenced by:

        • gonadotropin-releasing hormone receptor
          in basophil_gonadotroph_cell_of_anterior_pituitary_FSH
          • Correlation between the GnRH-stimulated release of both LH and SgII in vitro. [1]
          • Co-localization and co-release of LH and SgII in vivo. [2]
          • SgII plays an important role in the regulated secretion of LH. [3]
          • Combined activin+GnRH induced a further increase over individual treatment levels, which appeared to be additive rather than synergistic. [3]
          • LH released in response to GnRH is co-released with SgII via a regulated secretory pathway and that the activinstimulated LH release is probably via a constitutive, SgII-granule-independent pathway. [3]
        • unspecified testosterone receptor 2
          in basophil_gonadotroph_cell_of_anterior_pituitary_FSH
          • Feedback inhibition of testosterone on the synthesis and secretion of LH from the pituitary. [4]
        • ER-alpha
          in basophil_gonadotroph_cell_of_anterior_pituitary_FSH
          • Action of estradiol is dependent upon its concentration. It can either in- or decrease the cells' responsiveness to GnRH. [5]
        • CXCR1
          in basophil_gonadotroph_cell_of_anterior_pituitary_FSH
          • CINC/gro suppresses rapid the basal LH secretion from normal anterior pituitary cells in a concentration-dependent manner. [6]
        • ACTRIIA
          in basophil_gonadotroph_cell_of_anterior_pituitary_FSH
          • Activin had a stimulatory effect on LH secretion, although this response was not dose dependent. [3]
          • Combined activin+GnRH induced a further increase over individual treatment levels, which appeared to be additive rather than synergistic. [3]
        • unspecified progesterone receptor
          in basophil_gonadotroph_cell_of_anterior_pituitary_FSH
          • Short exposure to physiological levels of progesterone in the range of early luteal phase levels has a stimulatory effect on LH secretion by acting directly at the pituitary level. [7]
        • NPFF-R1
          in pituitary_gland_of_diencephalon
          • Thus, GnIH/RFRP may inhibit gonadotropin synthesis and release by direct actions on the pituitary gland. [8]
      • Hormone: angiotensin II

      • Hormone: TRH

      • Hormone: VIP

      • Hormone: FST

      • Hormone: FSH

        Influenced by:

        • CXCR1
          in basophil_gonadotroph_cell_of_anterior_pituitary_FSH
          • CINC/gro suppresses rapid the basal FSH secretion from normal anterior pituitary cells in a concentration-dependent manner. [6]
        • ER-alpha:ER-beta
          in basophil_gonadotroph_cell_of_anterior_pituitary_FSH
          • Regulation of FSH release is through negative feedback of gonadal steroids, particularly estradiol, which act directly at the pituitary.
        • unspecified testosterone receptor 1
          in basophil_gonadotroph_cell_of_anterior_pituitary_FSH
          • Regulation of FSH release is through negative feedback of gonadal steroids, particularly testosterone, which act directly at the pituitary. [3]
        • ACTRIIA
          in basophil_gonadotroph_cell_of_anterior_pituitary_FSH
          • While FSH secretion in LbetaT2 cells was stimulated, in a dose-dependent manner, by activin alone, and was unaffected by GnRH alone, there was a synergistic effect between the two treatments. [3]
          • FSH produced in LbetaT2 cells under activin/GnRH stimulation is constitutively secreted via a granin-independent pathway. [3]
        • gonadotropin-releasing hormone receptor
          in basophil_gonadotroph_cell_of_anterior_pituitary_FSH
          • GnRH requires the presence of activin in order to exert its action. [3]
        • NPFF-R1
          in pituitary_gland_of_diencephalon
          • Thus, GnIH/RFRP may inhibit gonadotropin synthesis and release by direct actions on the pituitary gland. [8]
      • Hormone: secretogranin-2

        Influenced by:

        • gonadotropin-releasing hormone receptor
          in basophil_gonadotroph_cell_of_anterior_pituitary_FSH
          • Co-localization and co-release of LH and SgII in vivo. [2]
          • Close correlation between GnRH-stimulated release of both LH and SgII in vitro. [1]
      • Hormone: secretoneurin

        Influenced by:

        • gonadotropin-releasing hormone receptor
          in basophil_gonadotroph_cell_of_anterior_pituitary_FSH
          • Co-localization and co-release of LH and SgII in vivo. [2]
          • Close correlation between GnRH-stimulated release of both LH and SgII in vitro. [1]
      • Hormone: chromogranin A

        Influenced by:

        • gonadotropin-releasing hormone receptor
          in basophil_gonadotroph_cell_of_anterior_pituitary_FSH
          • CgA secretion was maintained by GnRH and reduced below control levels by transfer to activin only. [3]

      Receptors

      • Receptor: gonadotropin-releasing hormone receptor

        Induced phenotype:

        • hypogonadotropic hypogonadism
          • Hypogonadotropic hypogonadism can be caused by mutations in multiple genes, including the gonadotropin-releasing hormone receptor gene. [10]

        Influences:

        • LH
          • Correlation between the GnRH-stimulated release of both LH and SgII in vitro. [1]
          • Co-localization and co-release of LH and SgII in vivo. [2]
          • SgII plays an important role in the regulated secretion of LH. [3]
          • Combined activin+GnRH induced a further increase over individual treatment levels, which appeared to be additive rather than synergistic. [3]
          • LH released in response to GnRH is co-released with SgII via a regulated secretory pathway and that the activinstimulated LH release is probably via a constitutive, SgII-granule-independent pathway. [3]
        • FSH
        • secretoneurin
          • Co-localization and co-release of LH and SgII in vivo. [2]
          • Close correlation between GnRH-stimulated release of both LH and SgII in vitro. [1]
        • secretogranin-2
          • Co-localization and co-release of LH and SgII in vivo. [2]
          • Close correlation between GnRH-stimulated release of both LH and SgII in vitro. [1]
        • FSH
          • GnRH requires the presence of activin in order to exert its action. [3]
        • chromogranin A
          • CgA secretion was maintained by GnRH and reduced below control levels by transfer to activin only. [3]
      • Receptor: unspecified testosterone receptor 2

        Influences:

        • LH
          • Feedback inhibition of testosterone on the synthesis and secretion of LH from the pituitary. [4]
      • Receptor: ACTRIIA

        Influences:

        • FSH
          • While FSH secretion in LbetaT2 cells was stimulated, in a dose-dependent manner, by activin alone, and was unaffected by GnRH alone, there was a synergistic effect between the two treatments. [3]
          • FSH produced in LbetaT2 cells under activin/GnRH stimulation is constitutively secreted via a granin-independent pathway. [3]
        • LH
          • Activin had a stimulatory effect on LH secretion, although this response was not dose dependent. [3]
          • Combined activin+GnRH induced a further increase over individual treatment levels, which appeared to be additive rather than synergistic. [3]
      • Receptor: ER-alpha

        Influences:

        • FSH
          • The action of estradiol is dependent upon its concentration. It can either increase or decrease the responsiveness to GnRH. [5]
        • LH
          • Action of estradiol is dependent upon its concentration. It can either in- or decrease the cells' responsiveness to GnRH. [5]
      • Receptor: unspecified progesterone receptor

        Influences:

        • LH
          • Short exposure to physiological levels of progesterone in the range of early luteal phase levels has a stimulatory effect on LH secretion by acting directly at the pituitary level. [7]
      • Receptor: CXCR1

        Influences:

        • FSH
          • CINC/gro suppresses rapid the basal FSH secretion from normal anterior pituitary cells in a concentration-dependent manner. [6]
        • LH
          • CINC/gro suppresses rapid the basal LH secretion from normal anterior pituitary cells in a concentration-dependent manner. [6]
      • Receptor: ER-alpha:ER-beta

        Influences:

        • FSH
          • Regulation of FSH release is through negative feedback of gonadal steroids, particularly estradiol, which act directly at the pituitary.
      • Receptor: unspecified testosterone receptor 1

        Influences:

        • FSH
          • Regulation of FSH release is through negative feedback of gonadal steroids, particularly testosterone, which act directly at the pituitary. [3]
      Reference