Details for anatomical structure: bone marrow
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- General information
- Related structures
- Hormones
- Receptors
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- Top
- General information
- Related structures
- Hormones
- Receptors
-
Click to access the toolbox
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Synonyms
bone marrow, , Medulla ossiumGeneral information
The tissue filling the cavities of bones, having a stroma of reticular fibers and cells; the soft, spongy tissue found in the centre of most large bones that produces the cellular components of blood: white cells, red cells and plateletsLinks to other resources
Cytomer | cy0038433 |
Related structures
Larger structures
Substructures
Secreted hormones
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Hormone: lipocalin 2
- NGAL was expressed in bone marrow and in tissues that are prone to exposure to microorganisms. [1]
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Hormone: VEGF-165
- VEGF, its receptors (VEGFR-1, VEGFR-2) and neuropillin-1 (NRP-1) are expressed at variable levels in bone marrow. [2]
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Hormone: IL-11
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Hormone: CLC
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Hormone: IL-15
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Hormone: CXCL11
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Hormone: MCP-2
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Hormone: IL-7
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Hormone: PGI2
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Hormone: PGE2
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Hormone: IL-1F8
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Hormone: HCC-1
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Hormone: MPIF-1
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Hormone: PARC
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Hormone: adipsin
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Hormone: osteocalcin
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Hormone: fibronectin
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Hormone: bone sialoprotein 2
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Hormone: osteomodulin
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Hormone: annexin A2
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Hormone: sclerostin
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Hormone: WNT10B
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Hormone: BAFF
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Hormone: defensin alpha 1
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Hormone: stem cell growth factor
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Hormone: NmU-25
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Hormone: GDF-3
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Hormone: insulin-like peptide INSL5
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Hormone: CD5L
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Hormone: proteinase 3
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Hormone: elastase-2
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Hormone: GnRH-II (Isoform 1)
Receptors
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Receptor: PPARgamma1
- mRNA being detectable in spleen, bone marrow, liver, testis, skeletal muscle and brain [4]
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Receptor: histamine H4 receptor
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Receptor: TLR2
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Receptor: M-CSF-1-R
Induced phenotype:
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Receptor: thrombospondin receptor
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Receptor: laminin receptor
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Receptor: B-CAM
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Receptor: Vascular endothelial growth factor receptor 2
Induced phenotype:
- angiogenesis
- Recruitment of circulating endothelial precursors to sites of active angiogenesis is mediated through VEGFR2. [5]
- angiogenesis
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Receptor: Vascular endothelial growth factor receptor 1
Induced phenotype:
- hematopoiesis
- Inhibition of VEGFR1, but not VEGFR2, blockes HSC cell cycling, differentiation and hematopoietic recovery after bone marrow suppression. Placental growth factor (PlGF), which signals through VEGFR1, restored early and late phases of hematopoiesis following bone marrow suppression. PlGF promotes recruitment of VEGFR1(+) HSCs from a quiescent to a proliferative bone marrow microenvironment, favoring differentiation, mobilization and reconstitution of hematopoiesis. [6]
- hematopoiesis
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Receptor: neuropilin 1
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Receptor: ALCAM
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Receptor: glypican 1
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Receptor: TNFR1
Induced phenotype:
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Receptor: Sphingosine 1-phosphate receptor 4
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Receptor: Probable G-protein coupled receptor 132
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Receptor: relaxin receptor 2