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Details for anatomical structure: intestinal smooth muscle cell

EndoNet ID: ENC00060

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Synonyms

intestinal smooth muscle cell, ,

Links to other resources

Cytomer cy0052332

Larger structures

  • skeleton_muscle
  • muscle

Substructures

    Secreted hormones

    • Hormone: IGF-1

      Influenced by:

      • IGFBP-5 receptor
        in intestinal_smooth_muscle_cell
        • An IGFBP-5 receptor is present in human intestinal smooth muscle cells. Binding of IGFBP-5 to its cognate receptor activates both the p38 MAP kinase and Erk1/2 signaling cascades. Activation of these pathways by IGFBP-5 mediates jointly stimulation of growth and secretion of IGF-I. [1]

    Receptors

    • Receptor: CCK-2

      • CCK2R protein has been demonstrated in the stomach muscularis. [2]

      Induced phenotype:

      • induction of smooth muscle contraction
        • The CCK2 receptors mediate an inhibitory effect on human colonic smooth muscle and an inhihitory action of CCK on motor function of human distal colon. [3]

    • Receptor: IGFBP-5 receptor

      Influences:

      • IGF-1
        • An IGFBP-5 receptor is present in human intestinal smooth muscle cells. Binding of IGFBP-5 to its cognate receptor activates both the p38 MAP kinase and Erk1/2 signaling cascades. Activation of these pathways by IGFBP-5 mediates jointly stimulation of growth and secretion of IGF-I. [1]

    • Receptor: CCK-1

      • The human CCKR1 is expressed at Protein level in the smooth muscle cells of the intestine. [4]

      Induced phenotype:

      • induction of smooth muscle contraction
        • In the human colon, the CCK-induced contraction of the smooth muscle is mediated through the CCK1 receptor. [5]
    Reference