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Synonyms
pancreatic islets, Islands of Langerhans, islets of Langerhans, endocrine part of pancreas, islet tissue, Pars endocrina pancreatis
General information
Cellular masses varying from a few to hundreds of cells lying in the interstitial tissue of the pancreas; they are composed of different cell types that comprise the endocrine portion of the pancreas and are the source of insulin, glucagon, somatostatin and pancreatic polypeptide
Human islets release monocyte chemoattractant protein-1 (MCP-1), one of the most powerful macrophage chemokines, which may impair the fate of a transplant. [1]
Activins, members of the transforming growth factor-β (TGF-β) superfamily, govern embryonic axial patterning. [6]
ActRIIB-mediated signaling controls both AP pattern of the axial skeleton and lateral asymmetry of heart and lungs. [7]
Both ActRIIA and ActRIIB are expressed in the primordia of foregut organs, including lungs, stomach, intestines, and pancreas. [8]
Type II activin receptors are crucial for normal development of many foregut organs, and these receptors have a particularly critical role in development and function of the endocrine pancreas. [9]