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Details for anatomical structure: Leydig cell of testis

EndoNet ID: ENC00067

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Synonyms

Leydig cell of testis, interstitial cell, Endocrinocytus interstitialis

General information

secreting testosterone

Links to other resources

Cytomer cy0011220

Larger structures

    Substructures

      Secreted hormones

      • Hormone: testosterone

        Influenced by:

        • LHCGR-1
          in Leydig_cell_of_testis
          • Luteinizing hormone secretion from pituitary and subsequent activation of Luteinizing hormone receptor in Leydig cells at the onset of puberty promotes testosterone synthesis, required for secondary sexual characteristics in males. [1]
        • ACTH receptor
          in testis
          • The testicular melanocortin type 2 receptors appear to be functionally active since ACTH will stimulate testosterone production by the fetal and neonatal mouse testis which both contain fetal-type Leydig cells although the effects are lost in the postpubertal animal. [2]
        • G-protein coupled receptor GPCR33
          in Leydig_cell_of_testis
          • Osteocalcin favors male fertility is by increasing testosterone synthesis in Leydig cells. Testosterone, in turn, supports maturation and prevents apoptosis of germ cells [3]
      • Hormone: DHT

      Receptors

      • Receptor: G-protein coupled receptor GPCR33

        • These data identify Gprc6a as an osteocalcin receptor in Leydig cells. [4]

        Influences:

        • testosterone
          • Osteocalcin favors male fertility is by increasing testosterone synthesis in Leydig cells. Testosterone, in turn, supports maturation and prevents apoptosis of germ cells [3]
      • Receptor: LHCGR-1

        Influences:

        • testosterone
          • Luteinizing hormone secretion from pituitary and subsequent activation of Luteinizing hormone receptor in Leydig cells at the onset of puberty promotes testosterone synthesis, required for secondary sexual characteristics in males. [1]
      • Receptor: MC1R

      • Receptor: ER-beta

        Induced phenotype:

        • steroidogenesis
          • Estrogen regulates steroidogenesis by acting through ER alpha and ER beta in the Leydig cells. [5]
      • Receptor: calcitonin-receptor-like receptor

      • Receptor: PRLR

        Induced phenotype:

        • stimulation of testicular function
          • Prolactin increases the LH receptor number in Leydig cells. [6]
          • In general, prolactin stimulates testicular functions in most mammals. In Leydig cells, prolactin is involved in the maintenance of cellular morphology. [7]
      • Receptor: ER-alpha

        Induced phenotype:

        • steroidogenesis
          • Estrogen regulates steroidogenesis by acting through ER alpha and ER beta in the Leydig cells. [5]
      Reference