Details for anatomical structure: Leydig cell of testis
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- General information
- Related structures
- Hormones
- Receptors
-
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- Top
- General information
- Related structures
- Hormones
- Receptors
-
Click to access the toolbox
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Synonyms
Leydig cell of testis, interstitial cell, Endocrinocytus interstitialisGeneral information
secreting testosteroneLinks to other resources
Cytomer | cy0011220 |
Related structures
Larger structures
Substructures
Secreted hormones
-
Hormone: testosterone
Influenced by:
- LHCGR-1
in
Leydig_cell_of_testis
- Luteinizing hormone secretion from pituitary and subsequent activation of Luteinizing hormone receptor in Leydig cells at the onset of puberty promotes testosterone synthesis, required for secondary sexual characteristics in males. [1]
- ACTH receptor
in
testis
- The testicular melanocortin type 2 receptors appear to be functionally active since ACTH will stimulate testosterone production by the fetal and neonatal mouse testis which both contain fetal-type Leydig cells although the effects are lost in the postpubertal animal. [2]
- G-protein coupled receptor GPCR33
in
Leydig_cell_of_testis
- Osteocalcin favors male fertility is by increasing testosterone synthesis in Leydig cells. Testosterone, in turn, supports maturation and prevents apoptosis of germ cells [3]
- LHCGR-1
in
Leydig_cell_of_testis
-
Hormone: DHT
Receptors
-
Receptor: G-protein coupled receptor GPCR33
- These data identify Gprc6a as an osteocalcin receptor in Leydig cells. [4]
Influences:
- testosterone
- Osteocalcin favors male fertility is by increasing testosterone synthesis in Leydig cells. Testosterone, in turn, supports maturation and prevents apoptosis of germ cells [3]
-
Receptor: LHCGR-1
Influences:
- testosterone
- Luteinizing hormone secretion from pituitary and subsequent activation of Luteinizing hormone receptor in Leydig cells at the onset of puberty promotes testosterone synthesis, required for secondary sexual characteristics in males. [1]
- testosterone
-
Receptor: MC1R
-
Receptor: ER-beta
Induced phenotype:
- steroidogenesis
- Estrogen regulates steroidogenesis by acting through ER alpha and ER beta in the Leydig cells. [5]
- steroidogenesis
-
Receptor: calcitonin-receptor-like receptor
-
Receptor: PRLR
Induced phenotype:
-
Receptor: ER-alpha
Induced phenotype:
- steroidogenesis
- Estrogen regulates steroidogenesis by acting through ER alpha and ER beta in the Leydig cells. [5]
- steroidogenesis