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Details for anatomical structure: mast cell

EndoNet ID: ENC00078

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Synonyms

mast cell, mastocyte, heparinocyte, labrocyte, Granulocytus basophilus textus

General information

contain Heparin and Histamin

Links to other resources

Cytomer cy0011312

Larger structures

    Substructures

      Secreted hormones

      • Hormone: interleukin 6

      • Hormone: IL-4

        • IL-4 and IL-13 are two cytokines produced by T helper type 2 cells, mast cells, and basophils. [1]
      • Hormone: IL-13

        • IL-4 and IL-13 are two cytokines produced by T helper type 2 cells, mast cells, and basophils. [1]
      • Hormone: C-C motif chemokine 2

        • Molecular regulation of interleukin-13 and monocyte chemoattractant protein-1 expression in human mast cells by interleukin-1beta. [2]
      • Hormone: histamine

        Influenced by:

        • IgE receptor
          in mast_cell
        • CRF-R1
          in mast_cell
          • CRH activates mast cells via CRH-R1 to release of histamine and from there, vasodilation and increased vascular permeability. [3]
        • beta-2 adrenoreceptor
          in mast_cell
          • Beta2 adrenoreceptor inhibit the histamine release from mast cells. [4]
      • Hormone: PDGFA

      • Hormone: IL-3

        • Hematopoietic cytokines such as interleukin 3 (IL-3) and granulocyte-macrophage colony stimulating factor (GM-CSF), produced by activated T cells and mast cells, are potent growth factors for various hematopoietic cells, as well as immature multipotential hematopoietic progenitors. [6]
      • Hormone: GM-CSF

        • Hematopoietic cytokines such as interleukin 3 (IL-3) and granulocyte-macrophage colony stimulating factor (GM-CSF), produced by activated T cells and mast cells, are potent growth factors for various hematopoietic cells, as well as immature multipotential hematopoietic progenitors. [6]
      • Hormone: PAF

      • Hormone: VEGF-206

      • Hormone: LTB4

      • Hormone: VEGF-165

        Influenced by:

        • CRF-R1
          in mast_cell
          • Activation of corticotropin-releasing hormone receptor 1 leeds to selective release of VEGF without granulation.
      • Hormone: sphingosine 1-phosphate

        • Mast cells can secrete S1P when activated by thrombin or IgE-bound antigen, respectively. [7]

      Receptors

      • Receptor: beta-1 adrenoreceptor

        Induced phenotype:

        • negative regulation of angiogenesis
          • Blockade of β1- and β2-adrenoceptors increases the number of mast cells, promoting proliferation and differentiation of fibroblasts. Additionally, blockade of β1- and β2-adrenoceptors increases the migration of mast cells, resulting in increased angiogenesis. [8]
      • Receptor: beta-2 adrenoreceptor

        Induced phenotype:

        • negative regulation of angiogenesis
          • Blockade of β1- and β2-adrenoceptors increases the number of mast cells, promoting proliferation and differentiation of fibroblasts. Additionally, blockade of β1- and β2-adrenoceptors increases the migration of mast cells, resulting in increased angiogenesis. [8]

        Influences:

        • histamine
          • Beta2 adrenoreceptor inhibit the histamine release from mast cells. [4]
      • Receptor: histamine H4 receptor

      • Receptor: SCFR

      • Receptor: basigin

      • Receptor: IgE receptor

        Influences:

        • histamine
      • Receptor: IgE Fc receptor gamma-subunit

      • Receptor: IgE Fc receptor, alpha-subunit

      • Receptor: IgE Fc receptor, subunit beta

      • Receptor: CRF-R1

        Induced phenotype:

        • mast cell activation
          • Corticotropin-releasing hormone is secreted outside the brain where it exerts proinflammatory effects, possibly through mast cell activation. [9]

        Influences:

        • histamine
          • CRH activates mast cells via CRH-R1 to release of histamine and from there, vasodilation and increased vascular permeability. [3]
        • VEGF-165
          • Activation of corticotropin-releasing hormone receptor 1 leeds to selective release of VEGF without granulation.
      • Receptor: Transient receptor potential cation channel subfamily V member 1

        • VR1 expression was observed on dermal mast cells and mast cell line HMC1 both at the protein and at the mRNA levels. [10]

        Induced phenotype:

        • Pruritus
          • Vanilloid receptor subtype 1 (VR1) is an important regulator of the cutaneous neuroimmune system. [10]
          • Direct activation of VR1 on mast cells may lead to the release of mast cell mediators which then are able to induce pruritus by binding to histamine- and proteinase-activated-2 (PAR-2) receptors on sensory nerve fibers. [10]
      • Receptor: Sphingosine 1-phosphate receptor 1

        Induced phenotype:

        • positive regulation of mast cell chemotaxis
          • Loss of S1PR1 results in decreased chemotactic motility. [11]
          • The positive effect of S1PR1 on mast-cell chemotactic motility is counteracted by S1PR2 expression. [11]
      • Receptor: Sphingosine 1-phosphate receptor 2

        Induced phenotype:

        • negative regulation of mast cell degranulation
          • Loss of S1PR2 inhibits high-affinity Fc receptor for IgE-induced mast-cell degranulation (that is, the ability to release granule-stored mast-cell allergic mediators such as histamine). [12]
      Reference