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Details for anatomical structure: melanocyte

EndoNet ID: ENC00082

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Synonyms

melanocyte, melanodendrocyte, Melanocytus

General information

They produce melanin

Links to other resources

Cytomer cy0049136

Larger structures

    Substructures

      Secreted hormones

      • Hormone: FSH

        Influenced by:

        • thrombin receptor
          in brain
        • gonadotropin-releasing hormone receptor
          in basophil_gonadotroph_cell_of_anterior_pituitary_FSH
        • ER-alpha
          in basophil_gonadotroph_cell_of_anterior_pituitary_FSH
          • The action of estradiol is dependent upon its concentration. It can either increase or decrease the responsiveness to GnRH. [1]
      • Hormone: GROalpha

      • Hormone: FGF-2

      • Hormone: IL-1F9-1

      • Hormone: IL-1F5

      • Hormone: pigment epithelium-derived factor

      • Hormone: Dynamin-2

      Receptors

      • Receptor: MC1R

        Induced phenotype:

        • melanin synthesis
          • Alpha-MSH acts as an agonist by binding to melanocortin receptor 1 (MC1-R) and elevting intracellular cAMP to induce eumelanin synthesis in the follicular melanocytes. [2]
        • antiapoptotic effect
          • The antiapoptotic effect of alpha-MSH was linked to reduction in cyclopyrimidine dimers, the major UV-induced DNA photoproduct. The antiapoptotic effects of alpha-MSH and the reduction in UVB-induced cyclopyrimidine dimers were not observed in melanocytes expressing loss-of function mutation of MC-1R. [3]

        Influences:

        • MSH
      • Receptor: ACTH receptor

        Induced phenotype:

        • pigmentation
          • The ACTH receptors regulates, together with the MSH receptor, the pigmentation by controlling the relative amounts of eumelanin and phaeomelanin. [4]
      • Receptor: ALCAM

      • Receptor: Sphingosine 1-phosphate receptor 1

      Reference