Details for anatomical structure: melanocyte
- Top
- General information
- Related structures
- Hormones
- Receptors
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- Top
- General information
- Related structures
- Hormones
- Receptors
-
Click to access the toolbox
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Synonyms
melanocyte, melanodendrocyte, MelanocytusGeneral information
They produce melaninLinks to other resources
Cytomer | cy0049136 |
Related structures
Larger structures
Substructures
Secreted hormones
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Hormone: FSH
Influenced by:
- thrombin receptor in brain
- gonadotropin-releasing hormone receptor in basophil_gonadotroph_cell_of_anterior_pituitary_FSH
- ER-alpha
in
basophil_gonadotroph_cell_of_anterior_pituitary_FSH
- The action of estradiol is dependent upon its concentration. It can either increase or decrease the responsiveness to GnRH. [1]
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Hormone: GROalpha
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Hormone: FGF-2
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Hormone: IL-1F9-1
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Hormone: IL-1F5
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Hormone: pigment epithelium-derived factor
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Hormone: Dynamin-2
Receptors
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Receptor: MC1R
Induced phenotype:
- melanin synthesis
- Alpha-MSH acts as an agonist by binding to melanocortin receptor 1 (MC1-R) and elevting intracellular cAMP to induce eumelanin synthesis in the follicular melanocytes. [2]
- antiapoptotic effect
- The antiapoptotic effect of alpha-MSH was linked to reduction in cyclopyrimidine dimers, the major UV-induced DNA photoproduct. The antiapoptotic effects of alpha-MSH and the reduction in UVB-induced cyclopyrimidine dimers were not observed in melanocytes expressing loss-of function mutation of MC-1R. [3]
Influences:
- melanin synthesis
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Receptor: ACTH receptor
Induced phenotype:
- pigmentation
- The ACTH receptors regulates, together with the MSH receptor, the pigmentation by controlling the relative amounts of eumelanin and phaeomelanin. [4]
- pigmentation
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Receptor: ALCAM
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Receptor: Sphingosine 1-phosphate receptor 1