Details for anatomical structure: osteoclast
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- General information
- Related structures
- Hormones
- Receptors
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- Top
- General information
- Related structures
- Hormones
- Receptors
-
Click to access the toolbox
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Synonyms
osteoclast, osteophage, OsteoclastocytusGeneral information
The main function is to degrade and absorb old bone matrix; they are activated by parathyroid hormon.Links to other resources
Cytomer | cy0011461 |
Related structures
Larger structures
Substructures
Secreted hormones
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Hormone: BMP-3
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Hormone: osteopontin
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Hormone: CD40-L
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Hormone: bone sialoprotein 2
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Hormone: TGF-beta 1
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Hormone: annexin A2
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Hormone: interleukin 6
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Hormone: RANKL
Receptors
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Receptor: IL-1RII
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Receptor: IL-1RI
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Receptor: calcitonin receptor
Induced phenotype:
- osteoporosis
- The discovery that calcitonin is a selective inhibitor of osteoclastic activity more than 40 years ago led to the concept that calcitonin deficiency might be the cause of osteoporosis and that its administration might be the cure. [1]
- osteoporosis
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Receptor: PTHR1
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Receptor: OPG
Induced phenotype:
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Receptor: M-CSF-1-R
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Receptor: ER-alpha
Induced phenotype:
- negative regulation of osteoclast proliferation
- Estrognes attenuate osteclastogenesis and life span and stimulate osteoclast apoptosis via cell-autonomous actions mediated by DNA binding-independent action of ER alpha. [2]
- positive regulation of ossification
- negative regulation of osteoclast proliferation
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Receptor: EP3
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Receptor: EP4
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Receptor: RANK
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Receptor: vitronectin receptor
- The vitronectin receptor, one member of the integrin superfamily, has been shown to be expressed in osteoclasts. [4]
Induced phenotype:
- regulation of bone resorption
- The colocalization of vitronectin receptor and vinculin in podosome-like structures may indicate its role in the attachment of resting and migrating osteoclasts to bone surface. [5]
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Receptor: ER-beta
Induced phenotype:
- negative regulation of osteoclast proliferation
- Estrogen inhibits osteoclastogenesis. [6]
- negative regulation of osteoclast proliferation
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Receptor: CaSR
Induced phenotype:
- regulation of bone resorption
- The activation of CaSR leads to the down-regulation of osteoclastic activity. [7]
- regulation of bone resorption