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Details for anatomical structure: Sertoli cell

EndoNet ID: ENC00119

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Synonyms

Sertoli cell, sustentacular cell, nurse cell, nursing cell, foot cell,

General information

nurtures the developing sperm cells through the stages of spermatogenesis, providing both secretory and structural support.

Links to other resources

Cytomer cy0044762

Larger structures

  • parts_of_human_body
  • gonads
  • testis

Substructures

    Secreted hormones

    • Hormone: inhibin B

      • Support for the developing spermatogenic cells and form a blood-testis barrier to large molekular weight compounds.

      Influenced by:

      • follitropin receptor
        in Sertoli_cell

    • Hormone: AMH

      • This glycoprotein, produced by the Sertoli cells of the testis, causes regression of the Muellerian duct. It is also able to inhibit the growth of tumors derived from tissues of Muellerian duct origin. [1]

    • Hormone: DHH

    • Hormone: FSH

    Receptors

    • Receptor: follitropin receptor

      Influences:

      • inhibin B

    • Receptor: ER-beta

      Induced phenotype:

      • spermatogenesis
        • Estrogen promotes gametogenesis by acting through ER beta in the Sertoli cells. [2]

    • Receptor: PRLR

      Induced phenotype:

      • increase in FSH receptor number
        • In Sertoli cells, prolactin has been shown to increase FSH receptor numbers. [3]
    Reference