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Details for anatomical structure: substantia nigra

EndoNet ID: ENC00134

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substantia nigra, nucleus of basis pedunculi, Soemmering's substance, Substantia nigra

General information

A large cell mass, crescentic on transverse section, extending forward over the dorsal surface of the crus cerebri from the rostral border of the pons into the subthalamic region

Links to other resources

Cytomer cy0006113

Larger structures


      Secreted hormones

      • Hormone: NPB23

      • Hormone: NPB29


      • Receptor: dopamine receptor D2

      • Receptor: frizzled 10

      • Receptor: NPY2-R

      • Receptor: EAAT3

      • Receptor: CRF-R1

      • Receptor: 5-HT-2C

        • The location of 5-HT-2C recpetors is on postsynaptic sites of the substantia nigra. [1]


        • GABA
          • The selective activation of 5-HT2C receptors stimulates non-DA neurons in the substantia nigra pars reticulata (SNr) and mediate an increase in GABA extracellular levels in the SNr. [2]
      • Receptor: 5-hydroxytryptamine receptor 4

        Induced phenotype:

        • optpkinetic behavior
          • The expression of the 5-HT 4 receptors in the basal ganglia and substantia nigra indicates a role in the control of visuo-motor activity. [3]
      • Receptor: OPRL1