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Details for anatomical structure: chromaffin cell

EndoNet ID: ENC00170

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Synonyms

chromaffin cell, chromaffine cell, chromaphil cell, pheochrome cell,

Links to other resources

Cytomer cy0044716

Larger structures

    Substructures

      Secreted hormones

      • Hormone: epinephrine

      • Hormone: catestatin

        • Human catestatin was cleaved in pheochromocytoma chromaffin granules, with the major form, human chromogranin A340-372, bounded by dibasic sites. [1]

      • Hormone: norepinephrine

        Influenced by:

        • leptin receptor
          in paraventricular_nucleus_of_hypothalamus
          • Leptin lowers noradrenalin concentration in PNV [2]

      • Hormone: acetylcholine

        Influenced by:

        • M4
          in adrenal_medulla
          • Muscarinic receptor stimulation was also found to enhance nicotineinduced catecholamine secretion by 1.7-fold if muscarine wasa dded 30 s before nicotine addition. [3]
        • M1
          in adrenal_medulla
          • Muscarinic receptor stimulation was also found to enhance nicotineinduced catecholamine secretion by 1.7-fold if muscarine wasa dded 30 s before nicotine addition. [3]
        • M2
          in adrenal_medulla
          • Muscarinic receptor stimulation was also found to enhance nicotineinduced catecholamine secretion by 1.7-fold if muscarine wasa dded 30 s before nicotine addition. [3]
        • M3
          in adrenal_medulla
          • Muscarinic receptor stimulation was also found to enhance nicotineinduced catecholamine secretion by 1.7-fold if muscarine wasa dded 30 s before nicotine addition. [3]
        • M5
          in adrenal_medulla
          • Muscarinic receptor stimulation was also found to enhance nicotineinduced catecholamine secretion by 1.7-fold if muscarine wasa dded 30 s before nicotine addition. [3]

      • Hormone: ACTH

        Influenced by:

        • VPAC1
          in adrenal_medulla
          • There is proof that VIP and PACAP can also enhance aldosterone secretion indirectly, by eliciting the release from medullary chromaffin cells of catecholamines and adrenocorticotropic hormone, which in turn may act on the cortical cells in a paracrine manner. [4]
        • VPAC2
          in adrenal_medulla
          • There is proof that VIP and PACAP can also enhance aldosterone secretion indirectly, by eliciting the release from medullary chromaffin cells of catecholamines and adrenocorticotropic hormone, which in turn may act on the cortical cells in a paracrine manner. [4]

      Receptors

      • Receptor: VPAC1

        Induced phenotype:

        • positive regulation of catecholamine secretion
          • PAPAC38 concentration-dependently increases catecholamine secretion from AM tissue. [5]

      • Receptor: VPAC2

        Induced phenotype:

        • positive regulation of catecholamine secretion
          • PAPAC38 concentration-dependently increases catecholamine secretion from AM tissue. [5]

      • Receptor: PACAP-R-1

        • PACAP-R-1 expression exclusively occurs in the adrenal medulla. [5]

        Induced phenotype:

        • positive regulation of catecholamine secretion
          • PAPAC38 concentration-dependently increases catecholamine secretion from AM tissue. [5]
      Reference