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Details for anatomical structure: basophil corticotroph cell of anterior pituitary

EndoNet ID: ENC00176

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Synonyms

basophil corticotroph cell of anterior pituitary, chromophil cell, Endocrinocytus basophilus

General information

secreting adrenocorticotropic hormone

Links to other resources

Cytomer cy0011197

Larger structures

  • brain
  • pituitary_gland_of_diencephalon
  • adenohypophysis
  • central_nerve_system_element

Substructures

    Secreted hormones

    • Hormone: ACTH

      • The action of CRH on ACTH release is strongly potentiated by vasopressin, that is co-produced in increasing amounts when the hypothalamic paraventricular neurons are chronically activated. [1]
      • Vasopressin stimulates ACTH release in humans, oxytocin inhibits it. [1]
      • [2]
      • Pituitary corticotropic cells express a specific vasopressin receptor, called V1b or V3, through which vasopressin stimulates corticotropin secretion. [3]

      Influenced by:

      • insulin receptor
        in basophil_corticotroph_cell_of_anterior_pituitary
      • V1b
        in basophil_corticotroph_cell_of_anterior_pituitary
        • Vasopressin is an important regulator of pituitary adrenocorticotropin (ACTH) secretion, mainly by potentiating the stimulatory effect of corticotropin releasing hormone. [4]
        • Effect of vasopressin in the pituitary corticotrope cells are mediated by the vasopressin type 1b receptor subtype, which is coupled to phospholipase C, leading to increases in cytosolic calcium and activation of protein kinase C. [4]
      • CXCR1
        in basophil_corticotroph_cell_of_anterior_pituitary
        • CINC/gro stimulates ACTH secretion from anterior pituitary monolayer cultures with a substantial lag time. [5]

    • Hormone: MSH

    • Hormone: lipotropin beta

      Influenced by:

      • insulin receptor
        in basophil_corticotroph_cell_of_anterior_pituitary

    • Hormone: lipotropin gamma

    • Hormone: β-endorphin

    • Hormone: angiotensin II

    • Hormone: CLIP

    Receptors

    • Receptor: V1b

      Influences:

      • ACTH
        • Vasopressin is an important regulator of pituitary adrenocorticotropin (ACTH) secretion, mainly by potentiating the stimulatory effect of corticotropin releasing hormone. [4]
        • Effect of vasopressin in the pituitary corticotrope cells are mediated by the vasopressin type 1b receptor subtype, which is coupled to phospholipase C, leading to increases in cytosolic calcium and activation of protein kinase C. [4]

    • Receptor: insulin receptor

      Induced phenotype:

      • tertiary adrenal insufficiency
        • Tertiary adrenal insufficiency is the result of a hypothalamic disease and thereby a decrease in corticotropin releasing factor. [7]

      Influences:

      • ACTH
      • lipotropin beta

    • Receptor: orexin receptor 2

    • Receptor: CXCR1

      Influences:

      • ACTH
        • CINC/gro stimulates ACTH secretion from anterior pituitary monolayer cultures with a substantial lag time. [5]
    Reference