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Details for anatomical structure: basophil thyrotroph cell of anterior pituitary

EndoNet ID: ENC00177

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Synonyms

basophil thyrotroph cell of anterior pituitary, chromophil cell, Endocrinocytus basophilus

General information

secreting thyroid-stimulating hormone

Links to other resources

Cytomer cy0011198

Larger structures

    Substructures

      Secreted hormones

      • Hormone: TSH

        • SSTR2 and SSTR5 mediate suppression of GH and TSH secretion. [1]

        Influenced by:

        • sst2
          in basophil_thyrotroph_cell_of_anterior_pituitary
        • sst5
          in basophil_thyrotroph_cell_of_anterior_pituitary
        • TRH-R
          in basophil_thyrotroph_cell_of_anterior_pituitary
        • RAR
          in basophil_thyrotroph_cell_of_anterior_pituitary
          • Retinoic acid plays an important inhibitory role on in vivo secretion of TSH and this effect is unrelated to the thyroid status of the animals. [2]
        • neuromedin B receptor
          in basophil_thyrotroph_cell_of_anterior_pituitary
          • Neuromedin B acts as a constitutive autocrine TSH-release inhibitor. [3]
      • Hormone: galanin

      • Hormone: NPY

      • Hormone: TRH

        Influenced by:

        • TRH-R
          in basophil_thyrotroph_cell_of_anterior_pituitary
          • Stimulates thyroid-stimulating hormone (TSH) release from anterior pituitary [5]
      • Hormone: neuromedin B

        • The thyrotroph seems to be the cell responsible for neuromedin B synthesis, because in the rat pituitary the peptide was detected only in TSH cells. [3]

        Influenced by:

        • TRH-R
          in basophil_thyrotroph_cell_of_anterior_pituitary
          • Neuromedin B is downregulated by thyrotropinreleasing hormone (TRH). [3]

      Receptors

      • Receptor: thyroid stimulating hormone receptor

      • Receptor: sst2

        Influences:

        • TSH
      • Receptor: sst5

        Influences:

        • TSH
      • Receptor: TRH-R

        Induced phenotype:

        • Hypothyroidism
          • Tertiary hypothyroidism is the result of an failure of the hypothalamus to produce sufficient thyrotropin-releasing hormone. [6]

        Influences:

        • TSH
        • TRH
          • Stimulates thyroid-stimulating hormone (TSH) release from anterior pituitary [5]
        • neuromedin B
          • Neuromedin B is downregulated by thyrotropinreleasing hormone (TRH). [3]
      • Receptor: CXCR1

      • Receptor: RAR

        Influences:

        • TSH
          • Retinoic acid plays an important inhibitory role on in vivo secretion of TSH and this effect is unrelated to the thyroid status of the animals. [2]
      • Receptor: neuromedin B receptor

        • The local action is further supported by the detection of NB receptors within the gland. [3]

        Influences:

        • TSH
          • Neuromedin B acts as a constitutive autocrine TSH-release inhibitor. [3]
      Reference