Status
Please wait ...

Details for anatomical structure: basophil thyrotroph cell of anterior pituitary

EndoNet ID: ENC00177

To link to the content of EndoNet use the EndoNet ID that is given on the detail pages in the format ENX0000, where X is a place holder for the type of the component (e. g. R for receptor or C for anatomical structure).
As URL for the linking append this ID to the detail page for this type of component.
For an hormone that would be: 

http://endonet.bioinf.med.uni-goettingen.de/hormone/ENH00000

It is also possible to use the search of EndoNet to link to the right detail page. The URL should look like 

http://endonet.bioinf.med.uni-goettingen.de/search/ENC00000
If the search pattern is unambigious the user is directed to the corresponding detail page.

Synonyms

basophil thyrotroph cell of anterior pituitary, chromophil cell, Endocrinocytus basophilus

General information

secreting thyroid-stimulating hormone

Links to other resources

Cytomer cy0011198

Larger structures

  • brain
  • pituitary_gland_of_diencephalon
  • adenohypophysis
  • central_nerve_system_element

Substructures

    Secreted hormones

    • Hormone: TSH

      • SSTR2 and SSTR5 mediate suppression of GH and TSH secretion. [1]

      Influenced by:

      • sst2
        in basophil_thyrotroph_cell_of_anterior_pituitary
      • sst5
        in basophil_thyrotroph_cell_of_anterior_pituitary
      • TRH-R
        in basophil_thyrotroph_cell_of_anterior_pituitary
      • RAR
        in basophil_thyrotroph_cell_of_anterior_pituitary
        • Retinoic acid plays an important inhibitory role on in vivo secretion of TSH and this effect is unrelated to the thyroid status of the animals. [2]
      • neuromedin B receptor
        in basophil_thyrotroph_cell_of_anterior_pituitary
        • Neuromedin B acts as a constitutive autocrine TSH-release inhibitor. [3]

    • Hormone: galanin

    • Hormone: NPY

    • Hormone: TRH

      Influenced by:

      • TRH-R
        in basophil_thyrotroph_cell_of_anterior_pituitary
        • Stimulates thyroid-stimulating hormone (TSH) release from anterior pituitary [5]

    • Hormone: neuromedin B

      • The thyrotroph seems to be the cell responsible for neuromedin B synthesis, because in the rat pituitary the peptide was detected only in TSH cells. [3]

      Influenced by:

      • TRH-R
        in basophil_thyrotroph_cell_of_anterior_pituitary
        • Neuromedin B is downregulated by thyrotropinreleasing hormone (TRH). [3]

    Receptors

    • Receptor: thyroid stimulating hormone receptor

    • Receptor: sst2

      Influences:

      • TSH

    • Receptor: sst5

      Influences:

      • TSH

    • Receptor: TRH-R

      Induced phenotype:

      • Hypothyroidism
        • Tertiary hypothyroidism is the result of an failure of the hypothalamus to produce sufficient thyrotropin-releasing hormone. [6]

      Influences:

      • TSH
      • TRH
        • Stimulates thyroid-stimulating hormone (TSH) release from anterior pituitary [5]
      • neuromedin B
        • Neuromedin B is downregulated by thyrotropinreleasing hormone (TRH). [3]

    • Receptor: CXCR1

    • Receptor: RAR

      Influences:

      • TSH
        • Retinoic acid plays an important inhibitory role on in vivo secretion of TSH and this effect is unrelated to the thyroid status of the animals. [2]

    • Receptor: neuromedin B receptor

      • The local action is further supported by the detection of NB receptors within the gland. [3]

      Influences:

      • TSH
        • Neuromedin B acts as a constitutive autocrine TSH-release inhibitor. [3]
    Reference