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Details for anatomical structure: cell of intermediate pituitary

EndoNet ID: ENC00178

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Synonyms

cell of intermediate pituitary, , Endocrinocytus basophilus

General information

secreting melanocyte-stimulating hormone

Links to other resources

Cytomer cy0011199

Larger structures

    Substructures

      Secreted hormones

      • Hormone: MSH

        • http://www.gesundheit.de/roche/ro22500/r24123.000.html [1]

        Influenced by:

        • MC1R
          in melanocyte
        • MC1R
          in skin
        • melatonin 1 receptor
          in hypothalamus
        • dopamine receptor D2
          in cell_of_intermediate_pituitary
          • The secretion of melanocyte-stimulating hormone (MSH) by intermediate lobe cells is under the negative influence of the hypothalamus. The predominant role of the tubero-hypophyseal dopaminergic neurons in the inhibitory control of MSH secretion has been demonstrated in mammals. [2]
          • Dopamine (in perifusion model) was responsible for a dose-related inhibition of MSH secretion. [3]
        • TRH-R
          in cell_of_intermediate_pituitary
          • In amphibians, TRH stimulates MSH release in vitro and that the action of TRH is not mediated via an inhibition of the release of endogenous dopamine. [4]
          • TRH reverses the inhibitory effect of dopamine on MSH secretion. The effects of TRH and dopamine are additive. Thus, the intracellular events associated with TRH-induced stimulation and dopamine-induced inhibition of MSH release are not linked together. [3]
      • Hormone: ACTH

        Influenced by:

        • CaSR
          in mammary_gland
          • CaSR activation led to the stimulation of cAMP production, and PTHrP and ACTH secretion from these cells. [5]
        • CRF-R2
          in pituitary_gland_of_diencephalon
          • Inihibition of CRH in the hypothalamus inhibts secretion of ACTH in pituritary gland [6]

      Receptors

      • Receptor: TRH-R

        Influences:

        • MSH
          • In amphibians, TRH stimulates MSH release in vitro and that the action of TRH is not mediated via an inhibition of the release of endogenous dopamine. [4]
          • TRH reverses the inhibitory effect of dopamine on MSH secretion. The effects of TRH and dopamine are additive. Thus, the intracellular events associated with TRH-induced stimulation and dopamine-induced inhibition of MSH release are not linked together. [3]
      • Receptor: CRF-R1

      • Receptor: PRLR

      • Receptor: dopamine receptor D2

        • The dopamine receptor in the intermediate lobe can be assigned to the category of dopamine receptor designated D-2. [7]

        Influences:

        • MSH
          • The secretion of melanocyte-stimulating hormone (MSH) by intermediate lobe cells is under the negative influence of the hypothalamus. The predominant role of the tubero-hypophyseal dopaminergic neurons in the inhibitory control of MSH secretion has been demonstrated in mammals. [2]
          • Dopamine (in perifusion model) was responsible for a dose-related inhibition of MSH secretion. [3]
      Reference