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Details for anatomical structure: D cell

EndoNet ID: ENC00179

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Synonyms

D cell, delta cell,

General information

produces somatostatin; somatostatin inhibits insulin and glucagon secretion

Links to other resources

Cytomer cy0044733

Larger structures

    Substructures

      Secreted hormones

      • Hormone: gastrin

        • Co-localization of gastrin and CRH in D-cells was determined by immunocytochemistry. S.456 [1]
      • Hormone: CRH

      • Hormone: somatostatin

        • SST also inhibits pancreatic polypeptide as well as endogenous SST secretion from delta-cells through an autofeedback mechanism. [2]

        Influenced by:

        • sst2
          in D_cell
        • sst3
          in D_cell
        • sst1
          in D_cell
        • sst5
          in D_cell
        • CCK-1
          in D_cell
          • The CCK1 receptor mRNA and protein have been localized in the human gastric mucosa within D cells, where CCK can stimulate somatostatin secretion. [3]

      Receptors

      • Receptor: sst5

        Influences:

        • somatostatin
      • Receptor: sst1

        Influences:

        • somatostatin
      • Receptor: sst2

        Influences:

        • somatostatin
      • Receptor: sst3

        Influences:

        • somatostatin
      • Receptor: CCK-1

        • The CCK1 receptor mRNA and protein have been localized in the human gastric mucosa within D cells. [3]

        Influences:

        • somatostatin
          • The CCK1 receptor mRNA and protein have been localized in the human gastric mucosa within D cells, where CCK can stimulate somatostatin secretion. [3]
      Reference