Details for anatomical structure: alpha cell of islet of Langerhans
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- General information
- Related structures
- Hormones
- Receptors
-
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- Top
- General information
- Related structures
- Hormones
- Receptors
-
Click to access the toolbox
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Synonyms
alpha cell of islet of Langerhans, , Endocrinocytus alphaGeneral information
secreting glucagon; glucagon is raising the blood sugar level and is a catecholamine agonistLinks to other resources
Cytomer | cy0011209 |
Related structures
Larger structures
Substructures
Secreted hormones
-
Hormone: ghrelin
- Ghrelin is present in pancreatic alpha-cells of humans and rats and stimulates insulin secretion. [1]
-
Hormone: glucagon
Influenced by:
- sst2
in
alpha_cell_of_islet_of_Langerhans
- Subtype-selective SSTR expression in islet cells could be the basis of glucagon inhibition by SSTR2-selective compounds. [4]
- sst3 in alpha_cell_of_islet_of_Langerhans
- sst5 in alpha_cell_of_islet_of_Langerhans
- insulin receptor in alpha_cell_of_islet_of_Langerhans
- CCK-2
in
alpha_cell_of_islet_of_Langerhans
- The CCK-B/G receptor agonists gastrin and cholecystokinin stimulated the release of glucagon in a dose-dependent manner. [5]
- GLP-1R
in
alpha_cell_of_islet_of_Langerhans
- This is supported by the observation that GLP-1 also inhibits glucagon release from a glucagon-secreting cell line [6]
- sst2
in
alpha_cell_of_islet_of_Langerhans
-
Hormone: CRH
- Co-localization of CRH, GIP, PP and CCK in A-cells was determined by immunocytochemistry. S.456 [7]
-
Hormone: GIP
-
Hormone: pancreatic polypeptide
-
Hormone: cholecystokinin
-
Hormone: glicentin-related polypeptide
Receptors
-
Receptor: sst2
Influences:
-
Receptor: sst1
-
Receptor: sst5
Influences:
-
Receptor: sst3
Influences:
-
Receptor: insulin receptor
Influences:
-
Receptor: GLP-1R
- The effects of GLP-1 or exenatide on glucagon levels during stepped hyperglycaemic and hypoglycaemic clamps provided the first information about GLP-1 receptor activation and alpha cell glucose sensing in human subjects. [6]
Influences:
-
Receptor: CCK-2
Influences: