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Details for anatomical structure: G cell

EndoNet ID: ENC00201

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Synonyms

G cell, APUD cell,

Links to other resources

Cytomer cy0045847

Larger structures

    Substructures

      Secreted hormones

      • Hormone: gastrin-6

      • Hormone: gastrin

        • Progastrin is synthesized in antral G cells and processed into a number of bioactive peptides, of which the heptadecapeptide gastrin-17 is the main product. [1]

        Influenced by:

        • PPAR-alpha
          in G_cell
          • PPARalpha agonists stimulate progastrin production. [2]
        • EGFR isoform a
          in G_cell
          • Activation of the canonical MAPK pathway by EGF stimulates gastrin gene expression via phosphorylation of Sp1. [3]
        • CaSR
          in G_cell
        • CCK-2
          in D_cell_of_gastrointestinal_tract
          • Gasrin secretion is inhibitted by gastric acid, probably via the paracrine mediator somatostatin [4]

      Receptors

      • Receptor: M3

      • Receptor: PPAR-alpha

        Influences:

        • gastrin
          • PPARalpha agonists stimulate progastrin production. [2]
      • Receptor: EGFR isoform a

        Influences:

        • gastrin
          • Activation of the canonical MAPK pathway by EGF stimulates gastrin gene expression via phosphorylation of Sp1. [3]
      • Receptor: CaSR

        Influences:

        • gastrin
      Reference