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Details for anatomical structure: G cell

EndoNet ID: ENC00201

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Synonyms

G cell, APUD cell,

Links to other resources

Cytomer cy0045847

Larger structures

  • stomach
  • parts_of_human_body
  • digestive_system
  • mucosa_of_gastric_wall
  • pancreas

Substructures

    Secreted hormones

    • Hormone: gastrin-6

    • Hormone: gastrin

      • Progastrin is synthesized in antral G cells and processed into a number of bioactive peptides, of which the heptadecapeptide gastrin-17 is the main product. [1]

      Influenced by:

      • PPAR-alpha
        in G_cell
        • PPARalpha agonists stimulate progastrin production. [2]
      • EGFR isoform a
        in G_cell
        • Activation of the canonical MAPK pathway by EGF stimulates gastrin gene expression via phosphorylation of Sp1. [3]
      • CaSR
        in G_cell
      • CCK-2
        in D_cell_of_gastrointestinal_tract
        • Gasrin secretion is inhibitted by gastric acid, probably via the paracrine mediator somatostatin [4]

    Receptors

    • Receptor: M3

    • Receptor: PPAR-alpha

      Influences:

      • gastrin
        • PPARalpha agonists stimulate progastrin production. [2]

    • Receptor: EGFR isoform a

      Influences:

      • gastrin
        • Activation of the canonical MAPK pathway by EGF stimulates gastrin gene expression via phosphorylation of Sp1. [3]

    • Receptor: CaSR

      Influences:

      • gastrin
    Reference