Details for anatomical structure: hair follicle
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- General information
- Related structures
- Hormones
- Receptors
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- Top
- General information
- Related structures
- Hormones
- Receptors
-
Click to access the toolbox
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Synonyms
hair follicle, , Folliculus piliGeneral information
A tube-like invagination of the epidermis from which the hair shaft develops and into which the sebaceous glands open; the follicle is lined by a cellular inner and outer root sheath of epidermal origin and is invested with a fibrous sheath derived from the dermisLinks to other resources
Cytomer | cy0049211 |
Related structures
Larger structures
Substructures
Secreted hormones
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Hormone: SHH
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Hormone: ectodysplasin-A
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Hormone: CST6
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Hormone: cortisol
Influenced by:
- CRF-R1
in
hair_follicle
- Isolated human hair follicles secrete substantial levels of cortisol and this activity is further up-regulated by CRH. [1]
- CRF-R1
in
hair_follicle
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Hormone: CRH
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Hormone: ACTH
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Hormone: alpha-MSH
Receptors
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Receptor: ER-alpha
Induced phenotype:
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Receptor: PR B
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Receptor: progesterone receptor A
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Receptor: ER-beta
Induced phenotype:
- hair growth
- ER beta is strongly expressed in human scalp anagen hair follicles. [4]
- Estrogens appear to stimulate hair growth in man, via prolonging the anagen phase of scalp hair growth by increasing cell proliferation rates and postponing their transition to the telogen phase.
- hair growth
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Receptor: AR
Induced phenotype:
- hair growth
- Androgens have strong effects on hair growth and appear to act through the AR on dermal papilla cells. [2]
- alopecia
- Single nucleotide polymorohisms of the AR have been associated with androgenetic alopecia in men. [5]
- hirsutism
- Single nucleotide polymorphisms of the AR have been associated with hirsutism in women. [6]
- hair growth
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Receptor: MC1R
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Receptor: CRF-R1
Induced phenotype:
- hair follicle maturation
- Corticotropin releasing hormone modulates important functional hair growth parameters in vitro (hair shaft elongation, catagen induction, hair keratinocyte proliferation, melanin production). [1]
- positive regulation of transcription
- Microdissected, organ-cultured human scalp hair follicles respond to CRH stimulation by up-regulating proopiomelanocortin (POMC) transcription and immunoreactivity for ACTH and α-MSH, which must have been processed from POMC. [1]
Influences:
- hair follicle maturation
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Receptor: EDAR
Induced phenotype:
- hair follicle maturation
- EDAr regulates the transition from active growth to regression (catagen) during hair follicle maturation. [7]
- hair follicle maturation
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Receptor: FGF-BP
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Receptor: ACTH receptor
Induced phenotype:
- cellular response to cortisol stimulus
- The strongest stimulus for adrenal cortisol production, ACTH, up-regulates cortisol immunoreactivity in the hair follicles. [1]
- cellular response to cortisol stimulus
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Receptor: Lysophosphatidic acid receptor 6
Induced phenotype:
- autosomal recessive woolly hair
- P2Y5 was identified as a critical mediator for human hair growth and is a causal gene of a rare familial form of human hair loss. [8]
- autosomal recessive woolly hair
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Receptor: Lysophosphatidic acid receptor 3
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Receptor: PRLR
Induced phenotype:
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Receptor: Lysophosphatidic acid receptor 1
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Receptor: Lysophosphatidic acid receptor 2