Details for anatomical structure: sebaceous glands
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- General information
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- Receptors
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- General information
- Related structures
- Hormones
- Receptors
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Click to access the toolbox
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Synonyms
sebaceous glands, oil glands, sebaceous follicles, Glandulae sebaceaeGeneral information
Numerous holocrine glands in the dermis that usually open into the hair follicles and secrete an oily semifluid sebumLinks to other resources
Cytomer | cy0000434 |
Related structures
Larger structures
Substructures
Secreted hormones
Receptors
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Receptor: ER-alpha
Induced phenotype:
- sebaceous gland development
- Systematically administered estrogen elicits a reduction in the size and secretion of sebaceous glands both in men and women, but this effect is usually achieved only with doses that exceed the physiologic requirement of women and produce feminization in men. [2]
- sebaceous gland development
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Receptor: ER-beta
Induced phenotype:
- sebaceous gland development
- Systematically administered estrogen elicits a reduction in the size and secretion of sebaceous glands both in men and women, but this effect is usually achieved only with doses that exceed the physiologic requirement of women and produce feminization in men. [2]
- sebaceous gland development
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Receptor: PR B
Induced phenotype:
-
Receptor: progesterone receptor A
Induced phenotype:
-
Receptor: AR
Induced phenotype:
- sebaceous gland development
- The development of the sebaceous gland depends on androgens. The administration of testosterone to castrated males, children or postmenopausal women in whom sebaceous secretion is normally low results in significant increase in sebaceous gland activity. Thus, the sebaqueous gland is an androgen target-organ. [2]
- sebaceous gland development
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Receptor: CRF-R1
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Receptor: melanocortin receptor 5
Induced phenotype:
- sebogenesis
- Since sebaceous glands of mice dereived from skin express MC5-R and targeted disruption of it results in reduced water repulsion and sebum secretion, it is possible that MC5-R in man likewise mediates sebogenesis. [4]
- sebaceous gland development
- Adrenal androgens may contribute significantly in sebaceous gland development. If neither estrogen nor ACTH has any directly supressive or stimulating effect respectively on the sebaqueous gland, the negative response to ACTH stimulation may mean either that endogenous androgens from the adrenal cortex are not sebum stimulating or that the estrogen together with pituitary-gonadal hormones supresses the adrenal gland directly. [2]
- sebogenesis