Details for anatomical structure: epidermis
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- General information
- Related structures
- Hormones
- Receptors
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- Top
- General information
- Related structures
- Hormones
- Receptors
-
Click to access the toolbox
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Synonyms
epidermis, , EpidermisGeneral information
The epithelial and superficial part of the skin which is derived from the embryonic epiblast; it consists of several layers of squamous epithelial cells, the outer ones of which are progressively more compressed and/or hornyLinks to other resources
Cytomer | cy0049127 |
Related structures
Larger structures
Substructures
Secreted hormones
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Hormone: IL-15
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Hormone: laminin gamma-2 chain
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Hormone: laminin beta-3 chain
Receptors
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Receptor: ER-alpha
Induced phenotype:
- regulation of water loss via skin
- The positive effects of estrogens on the water content of the skin, that were observed in all patients, may be due to dermal and epidermal components. The estrogen-stimulated increases of acid mucopolysaccharides and of hyaluronic acid contribute to an increase water content in the dermis. The increased epidermal water content may be due to increased epidermal skin thickness with subsequently elevated amounts of a natural moisturizing factor. [1]
- wound healing
- regulation of water loss via skin
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Receptor: ER-beta
Induced phenotype:
- regulation of water loss via skin
- The positive effects of estrogens on the water content of the skin, that were observed in all patients, may be due to dermal and epidermal components. The estrogen-stimulated increases of acid mucopolysaccharides and of hyaluronic acid contribute to an increase water content in the dermis. The increased epidermal water content may be due to increased epidermal skin thickness with subsequently elevated amounts of a natural moisturizing factor. [1]
- wound healing
- regulation of water loss via skin
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Receptor: PR B
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Receptor: progesterone receptor A
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Receptor: AR
Induced phenotype:
- negative regulation of epidermal barrier function
- Androgens stimulates epidermal hyperplasia and suppresses epidermal barrier function in fetal and adult human skin. [4]
- acne vulgaris
- Several experimental observations, therapeutic experience as well as clinical observations support the pathogenic role of androgens in acne. In addition to stimulation of sebum production, indirect evidence also suggests the importance of androgens on comedogenesis and inflammation. [5]
- negative regulation of epidermal barrier function
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Receptor: mineralcorticoid receptor
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Receptor: CRF-R1
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Receptor: PRLR