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Details for anatomical structure: growth plate

EndoNet ID: ENC00214

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Synonyms

growth plate, epiphysial plate, Lamina epiphysialis

Links to other resources

Cytomer cy0030973

Larger structures

    Substructures

      Secreted hormones

        Receptors

        • Receptor: AR

          Induced phenotype:

          • regulation of pubertal skeletal growth
            • Androgen probably augments pubertal skeletal growth by growth factor produciton at the growth plate. [1]
          • positive regulation of bone mineralization
            • Testosterone appears to help maintain bone formation and serves as a substrate for aromatization to estrogen in peripheral tissues including bone. [1]
        • Receptor: ER-alpha

          Induced phenotype:

          • regulation of pubertal skeletal growth
            • Estrogen is essential for normal pubertal skeletal growth and epiphyseal maturation in both males and females. [1]
          • positive regulation of bone mineralization
            • Estrogen is the major hormone responsible for the acquisition and maintenance of bone mass in male and female. [1]
          • positive regulation of ossification
            • ER alpha is expressed in the growth-plate cartilage and in bone. [2]
            • In aging men, estradiol is the dominant sex steroid regulating bone resorption, whereas both estradiol and testosterone are important in maintaining bone formation. [3]
        • Receptor: ER-beta

          Induced phenotype:

          • regulation of pubertal skeletal growth
            • Estrogen is essential for normal pubertal skeletal growth and epiphyseal maturation in both males and females. [1]
          • positive regulation of bone mineralization
            • Estrogen is the major hormone responsible for the acquisition and maintenance of bone mass in male and female. [1]
          • positive regulation of ossification
            • ER beta is expressed in the growth-plate cartilage and in bone. [2]
            • In aging men, estradiol is the dominant sex steroid regulating bone resorption, whereas both estradiol and testosterone are important in maintaining bone formation. [3]
        Reference