Status
Please wait ...

Details for anatomical structure: growth plate

EndoNet ID: ENC00214

To link to the content of EndoNet use the EndoNet ID that is given on the detail pages in the format ENX0000, where X is a place holder for the type of the component (e. g. R for receptor or C for anatomical structure).
As URL for the linking append this ID to the detail page for this type of component.
For an hormone that would be: 

http://endonet.bioinf.med.uni-goettingen.de/hormone/ENH00000

It is also possible to use the search of EndoNet to link to the right detail page. The URL should look like 

http://endonet.bioinf.med.uni-goettingen.de/search/ENC00000
If the search pattern is unambigious the user is directed to the corresponding detail page.

Synonyms

growth plate, epiphysial plate, Lamina epiphysialis

Links to other resources

Cytomer cy0030973

Larger structures

  • parts_of_human_body
  • bone

Substructures

  • osteoblast
  • macrophage
  • osteocyte
  • fibroblast

Secreted hormones

    Receptors

    • Receptor: AR

      Induced phenotype:

      • regulation of pubertal skeletal growth
        • Androgen probably augments pubertal skeletal growth by growth factor produciton at the growth plate. [1]
      • positive regulation of bone mineralization
        • Testosterone appears to help maintain bone formation and serves as a substrate for aromatization to estrogen in peripheral tissues including bone. [1]

    • Receptor: ER-alpha

      Induced phenotype:

      • regulation of pubertal skeletal growth
        • Estrogen is essential for normal pubertal skeletal growth and epiphyseal maturation in both males and females. [1]
      • positive regulation of bone mineralization
        • Estrogen is the major hormone responsible for the acquisition and maintenance of bone mass in male and female. [1]
      • positive regulation of ossification
        • ER alpha is expressed in the growth-plate cartilage and in bone. [2]
        • In aging men, estradiol is the dominant sex steroid regulating bone resorption, whereas both estradiol and testosterone are important in maintaining bone formation. [3]

    • Receptor: ER-beta

      Induced phenotype:

      • regulation of pubertal skeletal growth
        • Estrogen is essential for normal pubertal skeletal growth and epiphyseal maturation in both males and females. [1]
      • positive regulation of bone mineralization
        • Estrogen is the major hormone responsible for the acquisition and maintenance of bone mass in male and female. [1]
      • positive regulation of ossification
        • ER beta is expressed in the growth-plate cartilage and in bone. [2]
        • In aging men, estradiol is the dominant sex steroid regulating bone resorption, whereas both estradiol and testosterone are important in maintaining bone formation. [3]
    Reference