Details for anatomical structure: keratinocyte
- Top
- General information
- Related structures
- Hormones
- Receptors
-
Click to access the toolbox
- Top
- General information
- Related structures
- Hormones
- Receptors
-
Click to access the toolbox
To link to the content of EndoNet use the EndoNet ID that is given on the detail
pages in the format ENX0000, where X is a place holder for the type of
the component (e. g. R for receptor or C for anatomical structure).
As URL
for the linking append this ID to the detail page for this type of component.
For an hormone that would be:
http://endonet.bioinf.med.uni-goettingen.de/hormone/ENH00000
It is also possible to use the search of EndoNet to link to the right detail page. The URL should look like
http://endonet.bioinf.med.uni-goettingen.de/search/ENC00000If the search pattern is unambigious the user is directed to the corresponding detail page.
Synonyms
keratinocyte, malpighian cell,General information
produces keratin in the process of differentiating into the dead and fully keratinized cells of the stratum corneumLinks to other resources
Cytomer | cy0045842 |
Related structures
Larger structures
Substructures
Secreted hormones
-
Hormone: PAI-1
- The protease inhibitor PAI-1 has an essential role in cell motility, and its growth factor-initiated transcription in keratinocytes is regulated by USF elements. [1]
-
Hormone: MIG
-
Hormone: TGF-beta 1
- TGFbeta1, a potent keratinocyte growth inhibitor, has been shown to be overexpressed in keratinocytes in certain inflammatory skin diseases. [2]
-
Hormone: vitamin D3
- The main source of vitamin D is its synthesis in human skin. 7-Dehydrocholesterol converts into cholecalciferol (vitamin D3) as a result of UV radiation. [3]
- The major source of vitamin D (D3 cholecalciferol and D2 ergocalciferol) is synthesis from 7-dehydrocholesterol in the keratinocytes of the skin. [4]
-
Hormone: PTHLH
-
Hormone: IP-10
-
Hormone: cathelicidin
- Keratinocyte synthesis and processing of cathelicidin contribute to skin innate immunity by forming a direct antimicrobial defense barrier that supplements circulating immune cells. [5]
Influenced by:
- VDR
in
keratinocyte
- We provide evidence that the CAMP gene is a direct target of the transcription factor vitamin D receptor (VDR) that mediates the strong up-regulation of CAMP in response to treatment of cells with vitamin D3 [6]
-
Hormone: CXCL11
-
Hormone: IL-18
-
Hormone: IL-1F5
- In vitro-cultured keratinocytes contained ~10-fold more IL-1{delta} mRNA relative to IL-1{epsilon} mRNA. [7]
-
Hormone: thrombospondin 1
-
Hormone: laminin gamma-2 chain
-
Hormone: ECM1b
-
Hormone: CTGF
-
Hormone: ectodysplasin-A
-
Hormone: CST6
-
Hormone: PD-L1
-
Hormone: BD-2
-
Hormone: IL-23
-
Hormone: galectin-7
-
Hormone: FABP5
- Is highly expressed in psoriatic skin.
-
Hormone: EGF
-
Hormone: FGF-2
-
Hormone: PAI-2
-
Hormone: IL-1F9-1
Receptors
-
Receptor: MC1R
-
Receptor: CD44 isoform 1
-
Receptor: macrophage-stimulating protein receptor
Induced phenotype:
- wound healing
- The MSP/RON (receptor for MSP) system promotes wound healing. [8]
- wound healing
-
Receptor: frizzled 3
-
Receptor: integrin alpha-6/beta-4
-
Receptor: integrin alpha-3/beta-1
-
Receptor: EDAR
-
Receptor: CaSR
Induced phenotype:
- keratinocyte differentiation
- Epidermal expression of CaSR is required for the terminal differentiation of keratinocytes mediated by the stringent control of extracellular calcium levels. [9]
- keratinocyte differentiation
-
Receptor: IL-15R alpha
-
Receptor: ADAM17
-
Receptor: ALCAM
-
Receptor: TrpV4-A
Induced phenotype:
-
Receptor: Sphingosine 1-phosphate receptor 1
-
Receptor: Sphingosine 1-phosphate receptor 3
-
Receptor: Sphingosine 1-phosphate receptor 2
-
Receptor: Sphingosine 1-phosphate receptor 4
-
Receptor: Sphingosine 1-phosphate receptor 5
-
Receptor: G-protein coupled receptor 4
Induced phenotype:
-
Receptor: VDR
- Epidermal keratinocytes not only synthesize vitamin D by a photochemical process, they also contain the vitamin D receptor. [13]
Influences:
- cathelicidin
- We provide evidence that the CAMP gene is a direct target of the transcription factor vitamin D receptor (VDR) that mediates the strong up-regulation of CAMP in response to treatment of cells with vitamin D3 [6]