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Details for anatomical structure: uterus

EndoNet ID: ENC00246

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Synonyms

uterus, womb, Uterus

General information

The hollow, thick walled muscular organ in which the impregnated ovum is developed into the child; it is about 7,5 cm in length in the nonpregnant woman and consists of a main portion, the body, with an elongated lower part, the neck, at the extremity of which is the opening; the upper rounded part, opposite to the os, is the fundus

Links to other resources

Cytomer cy0039313

Larger structures

    Substructures

      Secreted hormones

      • Hormone: IGF-1

      • Hormone: CSH1

      • Hormone: TFF3

      • Hormone: PDGFC

      • Hormone: laminin-5B

      • Hormone: CTGF

      • Hormone: NPB23

      • Hormone: NPB29

      • Hormone: uteroglobin

      • Hormone: insulin-like peptide INSL5

      • Hormone: Oxytocin-Neurophysin 1

      Receptors

      • Receptor: ER-alpha

        Influences:

        • testosterone
          • Female estrogen receptor knock out mice develop glomerulosclerosis at 9 months of age due to excessive ovarian testosterone production and secretion. [2]
      • Receptor: ER-beta

        Influences:

        • testosterone
          • Female estrogen receptor knock out mice develop glomerulosclerosis at 9 months of age due to excessive ovarian testosterone production and secretion. [2]
      • Receptor: EP3

      • Receptor: EP4

      • Receptor: PGF2-alpha receptor

      • Receptor: angiotensin receptor 2

      • Receptor: kremen 2

      • Receptor: ADAM17

      • Receptor: ROBO1

      • Receptor: PRLR

        Induced phenotype:

        • increase in progesterone receptor level
          • In the uterus, prolactin is able to increase the level of progesterone receptors, and thus all actions associated with this steroid hormone are enhanced. [3]
        • increase in estrogen receptor level
          • In the uterus, prolactin has a stimulatory effect on estrogen receptor levels. [4]
        • embryo implantation
          • Prolactin promotes blastocyst implantation. [5]
        • uterine leiomyomas
          • Benign fibromuscular myometrial tumors (leiomyomas) have been shown to produce more PRL than control myometrium; thus, locally produced PRL may exert a mitogenic action on the growth of these tumors. [6]
      • Receptor: Lysophosphatidic acid receptor 3

        Induced phenotype:

        • embryo implantation
          • The most significant role of LPA signaling in reproductive function involves that of LPA3-mediated embryo implantation into the uterine wall. LPA3-deficient female mice showed delayed implantation, embryo crowding, and reduced litter size. [7]
      • Receptor: relaxin receptor 2

      Reference