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Details for anatomical structure: uterus

EndoNet ID: ENC00246

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Synonyms

uterus, womb, Uterus

General information

The hollow, thick walled muscular organ in which the impregnated ovum is developed into the child; it is about 7,5 cm in length in the nonpregnant woman and consists of a main portion, the body, with an elongated lower part, the neck, at the extremity of which is the opening; the upper rounded part, opposite to the os, is the fundus

Links to other resources

Cytomer cy0039313

Larger structures

  • parts_of_human_body

Substructures

  • alveolar_macrophage
  • B-lymphocyte
  • cell_of_adrenal_gland_zona_reticularis
  • T-lymphocyte
  • dendritic_cell_in_lymphoid_tissues_follicular
  • continuous_vascular_endothelial_cell_of_blood_vessels_and_lymphatics
  • neutrophil_granulocyte
  • cervical_canal_of_uterus
  • cervix_of_uterus
  • endocardium
  • lymphocyte
  • macrophage
  • cell_of_adrenal_gland_zona_fasciculata
  • fibroblast
  • muscularis_of_uterus
  • epithelial_cell_with_microvilli
  • cell:plasma_cell
  • cell_of_endometrium_of_uterus
  • smooth_muscle_cell
  • endothelial_cell
  • helper_T_cell_Th1
  • eosinophil_granulocyte
  • helper_T_cell_Th2
  • mast_cell
  • epithelial_cell
  • basophil_granulocyte

Secreted hormones

  • Hormone: IGF-1

  • Hormone: CSH1

  • Hormone: TFF3

  • Hormone: PDGFC

  • Hormone: laminin-5B

  • Hormone: CTGF

  • Hormone: NPB23

  • Hormone: NPB29

  • Hormone: uteroglobin

  • Hormone: insulin-like peptide INSL5

  • Hormone: Oxytocin-Neurophysin 1

Receptors

  • Receptor: ER-alpha

    Influences:

    • testosterone
      • Female estrogen receptor knock out mice develop glomerulosclerosis at 9 months of age due to excessive ovarian testosterone production and secretion. [2]

  • Receptor: ER-beta

    Influences:

    • testosterone
      • Female estrogen receptor knock out mice develop glomerulosclerosis at 9 months of age due to excessive ovarian testosterone production and secretion. [2]

  • Receptor: EP3

  • Receptor: EP4

  • Receptor: PGF2-alpha receptor

  • Receptor: angiotensin receptor 2

  • Receptor: kremen 2

  • Receptor: ADAM17

  • Receptor: ROBO1

  • Receptor: PRLR

    Induced phenotype:

    • increase in progesterone receptor level
      • In the uterus, prolactin is able to increase the level of progesterone receptors, and thus all actions associated with this steroid hormone are enhanced. [3]
    • increase in estrogen receptor level
      • In the uterus, prolactin has a stimulatory effect on estrogen receptor levels. [4]
    • embryo implantation
      • Prolactin promotes blastocyst implantation. [5]
    • uterine leiomyomas
      • Benign fibromuscular myometrial tumors (leiomyomas) have been shown to produce more PRL than control myometrium; thus, locally produced PRL may exert a mitogenic action on the growth of these tumors. [6]

  • Receptor: Lysophosphatidic acid receptor 3

    Induced phenotype:

    • embryo implantation
      • The most significant role of LPA signaling in reproductive function involves that of LPA3-mediated embryo implantation into the uterine wall. LPA3-deficient female mice showed delayed implantation, embryo crowding, and reduced litter size. [7]

  • Receptor: relaxin receptor 2

Reference