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Details for anatomical structure: basophil granulocyte

EndoNet ID: ENC00251

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Synonyms

basophil granulocyte, basophilocyte, Granulocytus basophilicus

General information

granulocytic leukocyte with an irregular nucleus, mostly invisible because of the similar colour of the basophilic granules; contains Histamin, Heparin, Peroxidase and Serotonin; their reaction to binding antigens ceases in the typical allergic reaction; ressembles in its function mast cells

Links to other resources

Cytomer cy0011311

Larger structures

    Substructures

      Secreted hormones

      • Hormone: IL-4

        • IL-4 and IL-13 are two cytokines produced by T helper type 2 cells, mast cells, and basophils. [1]
      • Hormone: IL-13

        • IL-4 and IL-13 are two cytokines produced by T helper type 2 cells, mast cells, and basophils. [1]
      • Hormone: histamine

        Influenced by:

        • IgE Fc receptor, alpha-subunit
          in basophil_granulocyte
          • PI3-kinase is involved in the signal transduction pathway responsible for histamine secretion following stimulation of Fc epsilon RI and that wortmannin blocks these responses through direct interaction with the catalytic subunit of this enzyme. [2]
      • Hormone: PAF

      Receptors

      • Receptor: histamine H4 receptor

      • Receptor: IL-5Ralpha

      • Receptor: IgE Fc receptor gamma-subunit

      • Receptor: CCR4

      • Receptor: IgE Fc receptor, subunit beta

      • Receptor: IgE Fc receptor, alpha-subunit

        Influences:

        • histamine
          • PI3-kinase is involved in the signal transduction pathway responsible for histamine secretion following stimulation of Fc epsilon RI and that wortmannin blocks these responses through direct interaction with the catalytic subunit of this enzyme. [2]
      • Receptor: complement C3d receptor

      Reference