Status
Please wait ...

Details for anatomical structure: chief cell of parathyroid gland

EndoNet ID: ENC00253

To link to the content of EndoNet use the EndoNet ID that is given on the detail pages in the format ENX0000, where X is a place holder for the type of the component (e. g. R for receptor or C for anatomical structure).
As URL for the linking append this ID to the detail page for this type of component.
For an hormone that would be:

http://endonet.bioinf.med.uni-goettingen.de/hormone/ENH00000

It is also possible to use the search of EndoNet to link to the right detail page. The URL should look like

http://endonet.bioinf.med.uni-goettingen.de/search/ENC00000
If the search pattern is unambigious the user is directed to the corresponding detail page.

Synonyms

chief cell of parathyroid gland, principal cell of parathyroid gland, Endocrinocytus parathyroideus

General information

A round clear cell with a centrally located nucleus; secreting parathyroid hormone

Links to other resources

Cytomer cy0011213

Larger structures

    Substructures

      Secreted hormones

      • Hormone: PTH

        • The active hormonal form of vitamin D, 1,25-dihydroxyvitamin D, and its analogues can reduce serum PTH levels by repressing PTH gene transcription and blocking parathyroid gland proliferation. These actions are mediated by the vitamin D receptor (VDR) present in the PTH-secreting chief cells of the parathyroid glands. [1]
        • The PTH-secretion is inhibited by high Ca 2+ and stimulated by low Ca 2+ concentrations detected by a calcium receptor on the cell surface of the chief cells. [2]

        Influenced by:

        • VDR
          in chief_cell_of_parathyroid_gland
          • Binding of extracellular calcium to the CaSR makes it possible to suppress the secretion of parathyroide hormone (PTH) from the parathyroid glands in patients with overactivity of these glands. [3]
        • ETA-R
          in chief_cell_of_parathyroid_gland
          • ET-1 dose-dependently (10e-10 -10e-7 M) inhibited basal PTH secretion by dispersed parathyroid adenoma cells. [4]
          • ET-1 displays an in vitro inhibitory effect on basal PTH secretion and also counteracts PTH hypersecretion stimulated by low calcium. [5]
        • ETB-R
          in chief_cell_of_parathyroid_gland
          • Higher concentrations (10e-8 - 10e-7 M) of ET-3 were required to inhibit PTH secretion. These data are consistent with the less predominant expression of ETB receptor subtype in the adenomatous tissue. [4]
      • Hormone: endothelin-1

        • Parathyroid cells express endothelin receptors and secrete ET-1 in an extracellular Ca2+ concentration dependent manner. [6]

      Receptors

      • Receptor: VDR

        Influences:

        • PTH
          • Binding of extracellular calcium to the CaSR makes it possible to suppress the secretion of parathyroide hormone (PTH) from the parathyroid glands in patients with overactivity of these glands. [3]
      • Receptor: ETA-R

        Influences:

        • PTH
          • ET-1 dose-dependently (10e-10 -10e-7 M) inhibited basal PTH secretion by dispersed parathyroid adenoma cells. [4]
          • ET-1 displays an in vitro inhibitory effect on basal PTH secretion and also counteracts PTH hypersecretion stimulated by low calcium. [5]
      • Receptor: ETB-R

        Influences:

        • PTH
          • Higher concentrations (10e-8 - 10e-7 M) of ET-3 were required to inhibit PTH secretion. These data are consistent with the less predominant expression of ETB receptor subtype in the adenomatous tissue. [4]
      Reference