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Details for anatomical structure: frontal lobe

EndoNet ID: ENC00275

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Synonyms

frontal lobe, ,

Links to other resources

Cytomer cy0052363

Larger structures

    Substructures

      Secreted hormones

      • Hormone: apelin-13

      • Hormone: apelin-28

      • Hormone: apelin-31

      • Hormone: apelin-36

      • Hormone: L-aspartate

        Influenced by:

        • 5-ht-6R
          in frontal_lobe
          • The stimulation of 5-HT6 receptor by the antagonist SB-271046 mediate a significant increase in extracellular aspartat concentration. [1]

      • Hormone: glutamate

        Influenced by:

        • 5-ht-6R
          in frontal_lobe
          • The stimulation of the 5-HT6 receptor by the antagonist SB-271046 produce a significant increase in extracellular glutamate concentration. [1]

      Receptors

      • Receptor: 5-hydroxytryptamine receptor 4

        Influences:

        • acetylcholine
          • The stimulation of 5-HT4 receptors increase the cortical ACh release in the frontal cortex. [2]
          • Stimualted 5-HT4 receptors increase the extracellular concentration of ACh in the frontal cortex. [3]

      • Receptor: GPR7

      • Receptor: Lysophosphatidic acid receptor 3

      • Receptor: dopamine receptor D4

      • Receptor: 5-HT3 receptor

        Influences:

        • acetylcholine
          • Acitvated 5-HT-3 receptors decreases the potassium-evoked release of acetycholine in slices of the central cortex. [4]
        • cholecystokinin
          • 5-HT mediated activation of 5-HT-3 receptors enhance the release of cholecystokinin in synaptosomes of the rat nucleus accumbens and cerebral cortex. [5]

      • Receptor: 5-ht-6R

        Influences:

        • glutamate
          • The stimulation of the 5-HT6 receptor by the antagonist SB-271046 produce a significant increase in extracellular glutamate concentration. [1]
        • L-aspartate
          • The stimulation of 5-HT6 receptor by the antagonist SB-271046 mediate a significant increase in extracellular aspartat concentration. [1]
        • acetylcholine
          • The stimulation of 5-HT6 receptors mediate an inhibitory serotoninergic effect to the ACh release in the frontal cortex. [6]
          • Constitutively activated 5-HT6 receptors inhibite cholinergic neurotransmission. [7]

      • Receptor: 5-HT-2A

        Influences:

        • acetylcholine
          • Acitvation of the 5-HT2 receptors stimulate the release of ACh in the prefontal cortex. [8]

      • Receptor: 5-HT-2B

        Influences:

        • acetylcholine
          • Acitvation of the 5-HT2 receptors stimulate the release of ACh in the prefontal cortex. [8]

      • Receptor: 5-HT-2C

        Influences:

        • acetylcholine
          • Acitvation of the 5-HT2 receptors stimulate the release of ACh in the prefontal cortex. [8]
      Reference