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Details for anatomical structure: fibroblast

EndoNet ID: ENC00283

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Synonyms

fibroblast, , Fibroblastocytus

General information

A cell deriving from the mesenchym, very active in secretion of extracellular matrix fiber; when metabolic decreases the cell transforms a fibrocyt

Links to other resources

Cytomer cy0011522

Larger structures

    Substructures

      Secreted hormones

      • Hormone: GROalpha

      • Hormone: PGE2

        • The CD40-CD40L interaction has been shown to stimulate prostaglandin and IL-8 release from fibroblasts. [1]
      • Hormone: IL-8

        • The CD40–CD40L interaction has been shown to stimulate prostaglandin and IL-8 release from fibroblasts. [1]
      • Hormone: GM-CSF

      • Hormone: M-CSF

      • Hormone: G-CSF

      • Hormone: IFN-beta

      • Hormone: eotaxin

        • Human eotaxin is an 8,3-kDa, 74-amino-acid residue, nonglycosylated polypeptide secreted by endothelial cells, fibroblasts, macrophages, ciliated and nonciliated bronchial epithelial cells, smooth muscle cells, chondrocytes, and eosinophils. [2]
      • Hormone: fibromodulin

      • Hormone: decorin

      • Hormone: thrombospondin 1

      • Hormone: tenascin-C

      • Hormone: gremlin-1

      • Hormone: WISP-2

      • Hormone: CTGF

      • Hormone: CYR61

      • Hormone: IL-20

      • Hormone: SDF-1alpha

      • Hormone: SDF-1beta

      • Hormone: PTHLH

      • Hormone: FGF-7

        Influenced by:

        • ER-beta
          in fibroblast
          • ER-beta variants, including ER-beta 1, ER-beta 2, ER-beta 5, ER-betadelta and ER-betains, but not ER-alpha, are expressed in human adult mammary fibroblasts. An ER-beta-selective ligand, BAG, but not the ER-alpha high-affinity ligand oestradiol, can induce fibroblast growth factor-7 release in adult human mammary fibroblasts. [3]
      • Hormone: TGF-beta 2

      • Hormone: PDGFB

      • Hormone: FGF-1 isoform 1

      • Hormone: FGF-2

      • Hormone: FGF-2

      • Hormone: pregnancy-associated plasma protein A

      • Hormone: PAI-2

      • Hormone: Dynamin-2

      • Hormone: cathepsin L

        • Both the synthesis and secretion of MEP are dramatically increased in response to tumor promoters, certain growth factors, and viral transformation. [4]
        • Although the biological function of secreted MEP is not known, the patterno f its regulation by growth factors and transforming agents suggests that it plays some important role in the growth of normal and transformed cells. [5]
      • Hormone: angiotensin II

        Influenced by:

        • angiotensin II type 1 receptor
          in fibroblast
          • In renal interstitial fibroblasts angiotensin II up-regulates angiotensinogen gene expression, thereby causing hyperplasia and extracellular matrix production via tha angiotensin type 1 receptor. [6]
      • Hormone: FGF-2

      • Hormone: interleukin 6

        • Fibroblast secretion of biologically active IL-6 has been reported in response to stimulation with both TNFa and IL-lalpha. [7]

      Receptors

      • Receptor: activin receptor type I

      • Receptor: MC1R

        Induced phenotype:

        • suppression of interstitial fibrosis
          • Alpha-MSH suppressed interstitial fibrosis induced by TGF-beta1 and reduced the number of vimentin and alpha-smooth muscle actin positive cells. [8]
      • Receptor: BMP receptor type II

      • Receptor: MRC2

      • Receptor: integrin beta-1

      • Receptor: IL-15R alpha

      • Receptor: ER-beta

        Influences:

        • FGF-7
          • ER-beta variants, including ER-beta 1, ER-beta 2, ER-beta 5, ER-betadelta and ER-betains, but not ER-alpha, are expressed in human adult mammary fibroblasts. An ER-beta-selective ligand, BAG, but not the ER-alpha high-affinity ligand oestradiol, can induce fibroblast growth factor-7 release in adult human mammary fibroblasts. [3]
      • Receptor: angiotensin II type 1 receptor

        Influences:

        • angiotensin II
          • In renal interstitial fibroblasts angiotensin II up-regulates angiotensinogen gene expression, thereby causing hyperplasia and extracellular matrix production via tha angiotensin type 1 receptor. [6]
        • angiotensin II
          • In renal interstitial fibroblasts angiotensin II up-regulates angiotensinogen gene expression, thereby causing hyperplasia and extracellular matrix production via tha angiotensin type 1 receptor. [6]
      • Receptor: Sphingosine 1-phosphate receptor 1

      • Receptor: Lysophosphatidic acid receptor 1

        Induced phenotype:

        • wound healing
          • Several lines of evidence suggest that LPA mediates wound healing.
          • LPA induced the closure of wounded endothelial monolayers in vitro. [9]
          • In vivo LPA application promoted repair processes in cutaneous wounds. [10]
          • In vivo LPA application promoted repair processes in intestinal wounds. [11]
          • Migration of fibroblasts into the fibrin wound matrix is an essential step in the wound-healing process in injured tissues, and LPA1 signaling regulates migration of mouse embryonic fibroblasts. [12]
      • Receptor: PDGFRalpha

        • Cardiac fibroblasts express PDGFR-alpha. [13]

        Induced phenotype:

        • proliferation of fibroblasts
          • PDGF-C, which binds to and activates the PDGF alpha-receptor, is activated by proteolysis and induces proliferation of fibroblasts when overexpressed in transgenic mice. [13]
      Reference