Details for anatomical structure: helper T cell Th1
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- General information
- Related structures
- Hormones
- Receptors
-
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- Top
- General information
- Related structures
- Hormones
- Receptors
-
Click to access the toolbox
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Synonyms
helper T cell Th1, inducer T cell, helper cell (Th 1), Lymphocytus (Th 1)General information
CD4-expressing T-lymphocyte; stimulates the production of antibodies by activating memory cells; also activates macrophagesLinks to other resources
Cytomer | cy0011314 |
Related structures
Larger structures
Substructures
Secreted hormones
-
Hormone: IFN-gamma
- Th1 cells mainly produce interferon-gamma, while Th2 cells selectively secrete IL-4 and IL-5. [1]
Influenced by:
- IL-18R
in
helper_T_cell_Th1
- IL-18 is originally called interferon gamma inducing factor, due to its capacity to induce interferon gamma production in Th1 type cells. [2]
-
Hormone: IL-2
- T-helper cells (Th1) produce interleukin (IL) -2 and interferon-gamma (IFN-gamma). [3]
Influenced by:
- CD28
in
helper_T_cell_Th1
- CD28 is the primary co-stimulatory receptor for inducing high-level IL-2 production and survival of naive CD4(+) T cells. [4]
-
Hormone: IL-4
- IL-4-secreting CD4+ T cells are crucial to the development of CD8+ T-cell responses against malaria liver stages. [5]
Receptors
-
Receptor: CCR4
-
Receptor: CD28
Influences:
-
Receptor: IL-18R1
-
Receptor: IL-12beta2R
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Receptor: IL-18Rbeta
-
Receptor: IL-18R
Influences:
-
Receptor: VPAC2
- Stimulation through the T cell receptors-associated CD3 complex induces the expression of the VPAC2-R mRNA in T-lymphocytes. [6]
Induced phenotype:
- cell maturation
- In CD4+CD8+thymocytes, PACAP prevents glucocorticoid-induced apoptosis by inhibiting Fas ligand expression, suggesting a possible implication in intrathymic T-cell maturation. [7]