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Details for anatomical structure: killer cell

EndoNet ID: ENC00292

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Synonyms

killer cell, null-cell, Lymphocytus

General information

Cellular cytotoxicity

Links to other resources

Cytomer cy0045844

Larger structures

    Substructures

      Secreted hormones

      • Hormone: IFN-gamma

        Influenced by:

        • IL-18R1
          in killer_cell
        • CD72
          in dendritic_cell_in_lymphoid_tissues
          • Activated NK cells express CD100 and produce soluble CD100. They interact with dendritic cells by several routs among which is the CD100-CD72 interaction. Such interaction lead to IFNgamma secretion which in turn activates other cells of the immune system. [1]
        • CD72
          in macrophage
          • Activated NK cells express CD100 and produce soluble CD100. They interact with macrophages by several routs among which is the CD100-CD72 interaction. Such interaction lead to IFNgamma secretion which in turn activates other cells of the immune system. [1]
      • Hormone: IL-22

      • Hormone: SEMA4D

        • IL-2 activated NK cells secrete soluble CD100. [1]

        Influenced by:

        • CD72
          in dendritic_cell_in_lymphoid_tissues
          • Activated NK cells express CD100 and produce soluble CD100. They interact with dentritic cells by several routs among which is the CD100-CD72 interaction. Such interaction lead to soluble CD100 secretion which in turn activates other cells of the immune system. [1]
        • CD72
          in macrophage
          • Activated NK cells express CD100 and produce soluble CD100. They interact with macrophages by several routs among which is the CD100-CD72 interaction. Such interaction lead to soluble CD100 secretion which in turn activates other cells of the immune system. [1]

      Receptors

      • Receptor: IL-12beta2R

      • Receptor: IL-18Rbeta

      • Receptor: IgE Fc receptor gamma-subunit

      • Receptor: SIGLEC-7

      • Receptor: IL-8R B

      • Receptor: CXCR1

      • Receptor: CXCR3

      • Receptor: CXCR5

      • Receptor: CXCR4

      • Receptor: CX3CR1

      • Receptor: CD160 antigen

      • Receptor: LIR-1

      • Receptor: CD7

      • Receptor: IL-18R1

        Influences:

        • IFN-gamma
      • Receptor: hLAIR1-1

      • Receptor: Sphingosine 1-phosphate receptor 5

        Induced phenotype:

        • positive regulation of leukocyte migration
          • NK cells rely on S1PR5 to attain a normal tissue distribution, which might also function to promote egress from the bone marrow and lymph nodes into the vascular compartments in response to S1P gradients. [2]
      Reference