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Details for anatomical structure: killer cell

EndoNet ID: ENC00292

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Synonyms

killer cell, null-cell, Lymphocytus

General information

Cellular cytotoxicity

Links to other resources

Cytomer cy0045844

Larger structures

  • circulatory_system__hematopoietic_system
  • immune_system
  • blood

Substructures

  • killer_T_cell

Secreted hormones

  • Hormone: IFN-gamma

    Influenced by:

    • IL-18R1
      in killer_cell
    • CD72
      in dendritic_cell_in_lymphoid_tissues
      • Activated NK cells express CD100 and produce soluble CD100. They interact with dendritic cells by several routs among which is the CD100-CD72 interaction. Such interaction lead to IFNgamma secretion which in turn activates other cells of the immune system. [1]
    • CD72
      in macrophage
      • Activated NK cells express CD100 and produce soluble CD100. They interact with macrophages by several routs among which is the CD100-CD72 interaction. Such interaction lead to IFNgamma secretion which in turn activates other cells of the immune system. [1]

  • Hormone: IL-22

  • Hormone: SEMA4D

    • IL-2 activated NK cells secrete soluble CD100. [1]

    Influenced by:

    • CD72
      in dendritic_cell_in_lymphoid_tissues
      • Activated NK cells express CD100 and produce soluble CD100. They interact with dentritic cells by several routs among which is the CD100-CD72 interaction. Such interaction lead to soluble CD100 secretion which in turn activates other cells of the immune system. [1]
    • CD72
      in macrophage
      • Activated NK cells express CD100 and produce soluble CD100. They interact with macrophages by several routs among which is the CD100-CD72 interaction. Such interaction lead to soluble CD100 secretion which in turn activates other cells of the immune system. [1]

Receptors

  • Receptor: IL-12beta2R

  • Receptor: IL-18Rbeta

  • Receptor: IgE Fc receptor gamma-subunit

  • Receptor: SIGLEC-7

  • Receptor: IL-8R B

  • Receptor: CXCR1

  • Receptor: CXCR3

  • Receptor: CXCR5

  • Receptor: CXCR4

  • Receptor: CX3CR1

  • Receptor: CD160 antigen

  • Receptor: LIR-1

  • Receptor: CD7

  • Receptor: IL-18R1

    Influences:

    • IFN-gamma

  • Receptor: hLAIR1-1

  • Receptor: Sphingosine 1-phosphate receptor 5

    Induced phenotype:

    • positive regulation of leukocyte migration
      • NK cells rely on S1PR5 to attain a normal tissue distribution, which might also function to promote egress from the bone marrow and lymph nodes into the vascular compartments in response to S1P gradients. [2]
Reference