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Details for anatomical structure: lymph node

EndoNet ID: ENC00306

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Synonyms

lymph node, , Nodus Lymphaticus

General information

Rounded mass of lymphoid tissue surrounded by a capsule of connectivum sited in various parts of the body in the course of the lymphatic vessels; numerous round, oval or bean-shaped bodies, varying greatly in size (1 to 25 mm in diameter) and usually presenting a depressed area, the hilum, on one side through which blood vessels enter and efferent lymph vessels emerge

Links to other resources

Cytomer cy0049566

Larger structures

    Substructures

      Secreted hormones

      • Hormone: BCA-1

      • Hormone: MIP-3 alpha

      • Hormone: MCP-4

      • Hormone: PARC

      • Hormone: BAFF

      • Hormone: CXCL16

      • Hormone: follicular dendritic cell secreted peptide

      • Hormone: IL-22

      • Hormone: IL-22BP

      • Hormone: CD5L

      • Hormone: FGF-23

      • Hormone: sphingosine 1-phosphate

        • In the lymph, S1P levels are in the hundred-nanomolar range. [1]

      Receptors

      • Receptor: TLR2

      • Receptor: TLR9

      • Receptor: TLR10

      • Receptor: RP105

        • Polymerase chain reaction analysis of isolated primary human cell populations confirms that mRNA exists in spleen B lymphocytes and monocytes but not T lymphocytes [2]
      • Receptor: laminin receptor

      • Receptor: TNFRSF18 isoform 1

        • The receptor is expressed in lymph node and peripheral blood leukocytes. [3]

        Induced phenotype:

        • leukocyte migration
          • TNFRSF18 and its ligand may be involved in activated T cell trafficking. [3]
      • Receptor: TNFRSF13C

        • Northern blot analysis on human tissues revealed that TNFRSF13C is expressed as a 4.5-kb mRNA in the secondary lymphoid organs. High levels of TNFRSF13C mRNA were detected in the lymph nodes. [4]

        Induced phenotype:

        • negative regulation of lymphocyte apoptosis
          • TNFRSF13C has a important role in mediating normal immune function. [5]
          • Mice expressing a mutant form of this receptor show severe defects in B-cell development and survival and in T lymphocate-dependent immune respose. [6]
      • Receptor: CCR9

      • Receptor: D6

      • Receptor: TCCR

      • Receptor: Sphingosine 1-phosphate receptor 4

      • Receptor: PAR1

        Induced phenotype:

        • positive regulation of myeloid dendritic cell activation
          • PAR1-mediated activation of DCs in the lymph nodes leads to SPHK1 activation and autocrine transactivation of S1PR3. [7]
      • Receptor: Probable G-protein coupled receptor 132

        Induced phenotype:

        • lymphocyte homeostasis
          • Disruption of G2A in mice leads to immunological disorders. The G2A(-/-) mice develop enlarged lymph nodes with abnormal expansion of both T- and B-lymphocytes. [8]
      • Receptor: G-protein coupled receptor 4

      • Receptor: Psychosine receptor

      • Receptor: Interleukin-22 receptor subunit alpha-1

        • issues that gave positive signals included placenta, skin, inflamed appendix, lung, gastrointestinal tract, lymph node, thymus, and spleen [9]
      Reference