Details for anatomical structure: lymph node
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- General information
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- Hormones
- Receptors
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- General information
- Related structures
- Hormones
- Receptors
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Synonyms
lymph node, , Nodus LymphaticusGeneral information
Rounded mass of lymphoid tissue surrounded by a capsule of connectivum sited in various parts of the body in the course of the lymphatic vessels; numerous round, oval or bean-shaped bodies, varying greatly in size (1 to 25 mm in diameter) and usually presenting a depressed area, the hilum, on one side through which blood vessels enter and efferent lymph vessels emergeLinks to other resources
Cytomer | cy0049566 |
Related structures
Larger structures
Substructures
Secreted hormones
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Hormone: BCA-1
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Hormone: MIP-3 alpha
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Hormone: MCP-4
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Hormone: PARC
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Hormone: BAFF
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Hormone: CXCL16
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Hormone: follicular dendritic cell secreted peptide
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Hormone: IL-22
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Hormone: IL-22BP
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Hormone: CD5L
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Hormone: FGF-23
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Hormone: sphingosine 1-phosphate
- In the lymph, S1P levels are in the hundred-nanomolar range. [1]
Receptors
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Receptor: TLR2
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Receptor: TLR9
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Receptor: TLR10
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Receptor: RP105
- Polymerase chain reaction analysis of isolated primary human cell populations confirms that mRNA exists in spleen B lymphocytes and monocytes but not T lymphocytes [2]
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Receptor: laminin receptor
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Receptor: TNFRSF18 isoform 1
- The receptor is expressed in lymph node and peripheral blood leukocytes. [3]
Induced phenotype:
- leukocyte migration
- TNFRSF18 and its ligand may be involved in activated T cell trafficking. [3]
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Receptor: TNFRSF13C
- Northern blot analysis on human tissues revealed that TNFRSF13C is expressed as a 4.5-kb mRNA in the secondary lymphoid organs. High levels of TNFRSF13C mRNA were detected in the lymph nodes. [4]
Induced phenotype:
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Receptor: CCR9
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Receptor: D6
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Receptor: TCCR
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Receptor: Sphingosine 1-phosphate receptor 4
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Receptor: PAR1
Induced phenotype:
- positive regulation of myeloid dendritic cell activation
- PAR1-mediated activation of DCs in the lymph nodes leads to SPHK1 activation and autocrine transactivation of S1PR3. [7]
- positive regulation of myeloid dendritic cell activation
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Receptor: Probable G-protein coupled receptor 132
Induced phenotype:
- lymphocyte homeostasis
- Disruption of G2A in mice leads to immunological disorders. The G2A(-/-) mice develop enlarged lymph nodes with abnormal expansion of both T- and B-lymphocytes. [8]
- lymphocyte homeostasis
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Receptor: G-protein coupled receptor 4
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Receptor: Psychosine receptor
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Receptor: Interleukin-22 receptor subunit alpha-1
- issues that gave positive signals included placenta, skin, inflamed appendix, lung, gastrointestinal tract, lymph node, thymus, and spleen [9]