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Details for anatomical structure: umbilical vein endothelial cells

EndoNet ID: ENC00412

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umbilical vein endothelial cells, HUVEC,

General information

Human Umbilical Vein Endothelial Cells (HUVEC) are isolated from normal human umbilical vein. They are cryopreserved at the end of primary culture and can be cultured and propagated at least 16 population doublings. HUVEC are responsive to cytokine stimulation in the expression of cell adhesion molecules. These cell systems are commonly used for physiological and pharmacological investigations, such as macromolecule transport, blood coagulation, and fibrinolysis.

Links to other resources

Cytomer cy0052330

Larger structures


      Secreted hormones

      • Hormone: PlGF-2

      • Hormone: VCAM1 soluble form

      • Hormone: soluble E-selectin

      • Hormone: vasorin

      • Hormone: endothelin-1

        Influenced by:

        • leptin receptor isoform b
          in continuous_vascular_endothelial_cell_of_blood_vessels_and_lymphatics
          • Leptin is able to upregulate ET-1 production in human umbilical vein endothelial cells. [1]


      • Receptor: hepatocyte growth factor receptor

      • Receptor: vasorin

      • Receptor: Sphingosine 1-phosphate receptor 1

        Induced phenotype:

        • venous endothelial cell differentiation
          • EDG1 was identied as an immediate-early gene product in phorbol ester-differentiated human umbilical vein endothelial cells, and was suggested to play a role in the morphogenetic differentiation of vascular endothelial cells into capillary-like tubules and in angiogenesis. [2]
      • Receptor: Lysophosphatidic acid receptor 1

        Induced phenotype:

        • positive regulation of cell death
          • In human umbilical vein endothelial cells (as well as porcine cerebral microvascular cells), LPA was found to induce oncotic cell death via protein nitrosylation. This endothelial cytotoxicity was reproduced in brain explants and retinas in vivo that exhibit diminished vasculature. This was reported to be LPA1 mediated. [3]