Status
Please wait ...

Details for anatomical structure: Schwann cell

EndoNet ID: ENC00419

To link to the content of EndoNet use the EndoNet ID that is given on the detail pages in the format ENX0000, where X is a place holder for the type of the component (e. g. R for receptor or C for anatomical structure).
As URL for the linking append this ID to the detail page for this type of component.
For an hormone that would be:

http://endonet.bioinf.med.uni-goettingen.de/hormone/ENH00000

It is also possible to use the search of EndoNet to link to the right detail page. The URL should look like

http://endonet.bioinf.med.uni-goettingen.de/search/ENC00000
If the search pattern is unambigious the user is directed to the corresponding detail page.

Synonyms

Schwann cell, , Neurolemmocytus

General information

encapsulating peripheral nerve cell bodies

Links to other resources

Cytomer cy0011352

Larger structures

    Substructures

      Secreted hormones

      • Hormone: laminin alpha-2 chain

      • Hormone: DHH

      Receptors

      • Receptor: Lysophosphatidic acid receptor 1

        Induced phenotype:

        • regulation of myelination
          • Schwann cells (SCs) are the myelinating cells of the peripheral nervous system. SCs express LPA1 and activation of this receptor is known to affect processes associated with myelination. [1]
        • regulation of actin cytoskeleton organization
          • LPA also induced dynamic regulation of the actin cytoskeleton and cellular adhesion properties in primary rat SCs, which suggests a critical role for LPA signaling in SC motility and myelination. [1]
        • negative regulation of glial cell apoptosis
          • LPA-mediated SC survival was confirmed in vivo, as mice deficient for LPA1 revealed increased apoptosis of SCs in the sciatic nerves. [2]
        • myelin formation in the peripheral nervous system
          • In addition to the role for myelination during developmental stages, evidence indicates a role for LPA signaling in remyelination after injuries such as neuropathic pain and nerve transection where LPA1 is upregulated despite very low levels under basal conditions. [3]
      • Receptor: Lysophosphatidic acid receptor 2

        Induced phenotype:

        • myelin formation in the peripheral nervous system
          • LPA2 signaling appears to be involved in SC function, because its activation results in the upregulation of myelin P0 protein in cultured SCs. [4]
        • myelin formation in the peripheral nervous system
          • In addition to the role for myelination during developmental stages, evidence indicates a role for LPA signaling in remyelination after injuries such as neuropathic pain and nerve transection where LPA2 is upregulated despite very low levels under basal conditions. [3]
        • regulation of myelination
          • Schwann cells (SCs) are the myelinating cells of the peripheral nervous system. SCs express LPA2, and activation of this receptor is known to affect processes associated with myelination. [5]
      Reference