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Details for anatomical structure: sinusoidal endothelial cell

EndoNet ID: ENC00429

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Synonyms

sinusoidal endothelial cell, ,

Links to other resources

Cytomer cy00552331

Larger structures

  • parts_of_human_body
  • digestive_system
  • liver

Substructures

    Secreted hormones

    • Hormone: ICAM-1

      • LSEC constitutively express high levels of adhesion molecules including ICAM-1, VCAM-1, L-SIGN and VAP-1. [1]
      • Strong staining in unstimulated LSEC and very strong staining in stimulated LSEC. [1]

    • Hormone: VCAM1 soluble form

    • Hormone: galectin-1

      • Galectin-1, a lectin which is specifically expressed on LSEC in the liver is known to bind to and induce apoptosis in activated T cells. [1]
      • Strong staining in unstimulated LSEC and very strong staining in stimulated LSEC. [1]

    • Hormone: TGF-beta 1

    • Hormone: FGF-18

      • FGF18 expression was detected in liver vascular and liver sinusoidal endothelial cells (LSECs), but not in hepatic parenchymal cells. [2]

    • Hormone: PD-L2

    • Hormone: endothelin-1

    Receptors

    • Receptor: Vascular endothelial growth factor receptor 2

      Induced phenotype:

      • regulation of endothelial cell differentiation
        • VEGFR2 signaling is required for capillary tube formation, it regulates the differentiation of endothelial cells into capillary tubes. [3]

    • Receptor: Vascular endothelial growth factor receptor 1

      Induced phenotype:

      • negative regulation of apoptosis
        • VEGFR1 signaling is critical for endothelial cell survival. [3]
        • VEGF enhances the survival of endothelial cells by regulating the activity of the anti-apoptotic Bcl-2 and inhibiting caspase-mediated cell death. [3]

    • Receptor: CD40

    • Receptor: Tie2

    • Receptor: fas receptor

    Reference