Details for anatomical structure: Goormaghtighs cell
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- General information
- Related structures
- Hormones
- Receptors
-
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- Top
- General information
- Related structures
- Hormones
- Receptors
-
Click to access the toolbox
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Synonyms
Goormaghtighs cell, juxtaglomerular cell,General information
located at the vascular pole of the renal corpuscle; they are modified smooth muscle cells primarily of the afferent arteriole of the renal glomerulus.Links to other resources
Cytomer | cy0011519 |
Related structures
Larger structures
Substructures
Secreted hormones
-
Hormone: renin
Influenced by:
- CaSR
in
Goormaghtighs_cell
- CaSRs modulate renin release both in vitro and in vivo. CaSRs play a role as a regulatory pathway of renin release. [1]
- Activation of CaSR significantly decreases both JG cell cAMP formation and renin release by ~45%. Juxtaglomerular cells express CaSR, and CaSR respond to changes in extracellular calcium to modify or activate calcium-mediated intracellular signaling. [2]
- While calcium does not directly control renin secretion, increased calcium inhibits and decreased calcium amplifies cAMP-stimulated renin secretion. [3]
- beta-1 adrenoreceptor
in
kidney
- renin secretion from juxtaglomerular cells is mediated by the action on β1-adrenoreceptors of norepinephrine released from renal sympathetic nerve terminals as a result of renal nerve activity [4]
- angiotensin II type 1 receptor
in
Goormaghtighs_cell
- Activation of AT1 receptors at the juxtaglomerular apparatus suppresses renin release through the so-called short-loop feedback mechanism. [5]
- NPR1 in kidney
- CaSR
in
Goormaghtighs_cell
Receptors
-
Receptor: CaSR
Influences:
- renin
- CaSRs modulate renin release both in vitro and in vivo. CaSRs play a role as a regulatory pathway of renin release. [1]
- Activation of CaSR significantly decreases both JG cell cAMP formation and renin release by ~45%. Juxtaglomerular cells express CaSR, and CaSR respond to changes in extracellular calcium to modify or activate calcium-mediated intracellular signaling. [2]
- While calcium does not directly control renin secretion, increased calcium inhibits and decreased calcium amplifies cAMP-stimulated renin secretion. [3]
- renin
-
Receptor: angiotensin II type 1 receptor
Influences: