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Details for anatomical structure: Müllers radial cell of retina

EndoNet ID: ENC00468

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Synonyms

Müllers radial cell of retina, , Gliocytus radialis

General information

retinal glia cell

Links to other resources

Cytomer cy0011430

Larger structures

  • brain
  • peripheral_nerve_system_element
  • retinal_pigment_epithelium_RPE
  • eye
  • spinal_cord
  • central_nerve_system_element
  • circulatory_system__hematopoietic_system
  • glial_cell_of_peripheral_nervous_system
  • parts_of_human_body
  • digestive_system
  • blood_vessel
  • retina
  • adrenal_gland
  • oesophagus
  • dorsal_root_ganglion
  • nerve

Substructures

    Secreted hormones

    • Hormone: VEGF-183

    • Hormone: VEGF-165

    Receptors

    • Receptor: Vascular endothelial growth factor receptor 2

      • Isolated retinal Muller cells express both VEGF1 and VEGFR2 receptors. [1]

      Induced phenotype:

      • regulation of neural retina development
        • Extravascular VEGFR-1 and -2 are necessary for normal neural retinal development independent of vascular development. [1]
        • Peripheral retina is normally avascular at birth and becomes vascularized over the first 2 weeks after birth. [2]
        • Inhibition of VEGFR-1 and -2 in vivo inhibits development of the nonvascularized immature retina, resulting in cell loss in the inner retina, including the inner nuclear layer containing Muller cells and the ganglion cell layer containing astrocytes. [1]

    • Receptor: Vascular endothelial growth factor receptor 1

      • Isolated retinal Muller cells express both VEGF1 and VEGFR2 receptors. [1]

      Induced phenotype:

      • regulation of neural retina development
        • Extravascular VEGFR-1 and -2 are necessary for normal neural retinal development independent of vascular development. [1]
        • Peripheral retina is normally avascular at birth and becomes vascularized over the first 2 weeks after birth. [2]
        • Inhibition of VEGFR-1 and -2 in vivo inhibits development of the nonvascularized immature retina, resulting in cell loss in the inner retina, including the inner nuclear layer containing Muller cells and the ganglion cell layer containing astrocytes. [1]
    Reference