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Details for anatomical structure: oligodendrocyte

EndoNet ID: ENC00472

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Synonyms

oligodendrocyte, , Oligodendrocytus

General information

Oligodendrocyte are present in both gray matter and white matter; forms the myelin sheaths in central nervous system.

Links to other resources

Cytomer cy0011359

Larger structures

    Substructures

      Secreted hormones

      • Hormone: APOD

      Receptors

      • Receptor: Sphingosine 1-phosphate receptor 5

        Induced phenotype:

        • regulation of myelination
          • S1P5 expressed by oligodendrocytes might play a role in normal myelination and in demyelinating diseases, such as multiple sclerosis, as its expression is restricted to oligodendrocytes throughout development from immature stages to myelin-forming cells. [1]
      • Receptor: integrin alpha-6/beta-1

      • Receptor: GLAST

        Induced phenotype:

        • excitotoxcicity
          • The uptake of glutamate from the synaptic cleft by GLAST is crucial for the termination of excitatory neurotransmission. thereby preventing pathologic excitotoxicity. [2]
      • Receptor: Lysophosphatidic acid receptor 1

        Induced phenotype:

        • myelin formation in the central nervous system
          • A significant role for LPA signaling in myelination was suggested by the Lpar1 gene expression pattern that spatially and temporally correlated with oligodendrocyte myelination. [3]
          • LPA has a positive effect on process formation and myelin basic protein production in oligodendrocytes. [4]
        • cell maturation
          • A significant role for LPA signaling in myelination was suggested by the Lpar1 gene expression pattern that spatially and temporally correlated with oligodendrocyte maturation. [5]
          • Oligodendrocytes, the myelin-forming glial cells in the CNS, express LPA1 and LPA3 during differentiation. [5]
      • Receptor: Lysophosphatidic acid receptor 3

      • Receptor: Psychosine receptor

        Induced phenotype:

        • positive regulation of glial cell apoptosis
          • Psy is primarily accumulated in oligodendroglia, which contain abundant GalCer, a precursor of Psy. The accumulated Psy is cytotoxic, and these cells were therefore injured or died on Psy accumulation, probably due to apoptosis. [6]
      Reference