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Details for anatomical structure: fat cell of brown fat

EndoNet ID: ENC00479

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Synonyms

fat cell of brown fat, ,

General information

multilocular, large cell; enourmous number of mitochondria (responsible for brown colour); main function is heatproduction (without the typical shiver-side effect), by uncoupling the oxidative phosphorylation with the help of Thermogenin;

Links to other resources

Cytomer cy0052322

Larger structures

    Substructures

      Secreted hormones

      • Hormone: leptin

        Influenced by:

        • PRLR
          in fat_cell_of_brown_fat
          • Prolactin combined with insulin significantly increases leptin expression and release from differentiated brown adipocytes, indicating that prolactin potentiates the stimulatory effect of insulin as revealed by the recruitment of insulin receptor substrates and the activation of phosphatidylinositol 3-kinase. [1]
          • Prolactin is not directly involved in transcription rate, but more likely in the secretion or release process of leptin in vivo. [1]

      Receptors

      • Receptor: PRLR

        Influences:

        • leptin
          • Prolactin combined with insulin significantly increases leptin expression and release from differentiated brown adipocytes, indicating that prolactin potentiates the stimulatory effect of insulin as revealed by the recruitment of insulin receptor substrates and the activation of phosphatidylinositol 3-kinase. [1]
          • Prolactin is not directly involved in transcription rate, but more likely in the secretion or release process of leptin in vivo. [1]
      Reference