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Details for anatomical structure: cerebral cortex

EndoNet ID: ENC00487

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Synonyms

cerebral cortex, , Cortex cerebri

General information

The outer layer of gray matter of the cerebrum and cerebellum

Links to other resources

Cytomer cy0018657

Larger structures

    Substructures

      Secreted hormones

      • Hormone: ADNP

      • Hormone: acetylcholine

        Influenced by:

        • 5-HT3 receptor
          in frontal_lobe
          • Acitvated 5-HT-3 receptors decreases the potassium-evoked release of acetycholine in slices of the central cortex. [1]
        • 5-ht-6R
          in frontal_lobe
          • The stimulation of 5-HT6 receptors mediate an inhibitory serotoninergic effect to the ACh release in the frontal cortex. [2]
          • Constitutively activated 5-HT6 receptors inhibite cholinergic neurotransmission. [3]
        • 5-hydroxytryptamine receptor 4
          in frontal_lobe
          • The stimulation of 5-HT4 receptors increase the cortical ACh release in the frontal cortex. [4]
          • Stimualted 5-HT4 receptors increase the extracellular concentration of ACh in the frontal cortex. [5]
        • 5-HT-2A
          in frontal_lobe
          • Acitvation of the 5-HT2 receptors stimulate the release of ACh in the prefontal cortex. [6]
        • 5-HT-2B
          in frontal_lobe
          • Acitvation of the 5-HT2 receptors stimulate the release of ACh in the prefontal cortex. [6]
        • 5-HT-2C
          in frontal_lobe
          • Acitvation of the 5-HT2 receptors stimulate the release of ACh in the prefontal cortex. [6]
        • alpha-2A adrenoreceptor
          in cerebellar_cortex
          • Alpha 2 adrenergic receptors mediate synaptic transmission in pre- and postsynaptic nerve terminals by decreasing the release of norepinephrine (due to the inhibition of the norepinephrine system in the brain) and acetylcholine. [7]
        • alpha-2B adrenoreceptor
          in cerebellar_cortex
          • Alpha 2 adrenergic receptors mediate synaptic transmission in pre- and postsynaptic nerve terminals by decreasing the release of norepinephrine (due to the inhibition of the norepinephrine system in the brain) and acetylcholine. [7]
        • alpha-2C adrenoreceptor
          in cerebellar_cortex
          • Alpha 2 adrenergic receptors mediate synaptic transmission in pre- and postsynaptic nerve terminals by decreasing the release of norepinephrine (due to the inhibition of the norepinephrine system in the brain) and acetylcholine. [7]

      Receptors

      • Receptor: ADAM17

      • Receptor: CB1

        Influences:

        • serotonin
          • Stimulation of the CB1 receptor results in the inhibition of a range of excitatory and inhibitory neurotransmitters, like acetylcholine, noradrenaline, dopamine, 5-hydroxytryptamine, D-aspartate and cholecystokinin. [8]
      • Receptor: mGluR1

        Influences:

        • sAPP
          • Glutamate-induced APP-S secretion required activation of phospholipase C, which resulted in inositol 1, 4,5-trisphosphate production, as shown by the rapid glutamate-induced accumulation of inositol 1,4,5-trisphosphate. [9]
      • Receptor: FGFR-2

        Induced phenotype:

        • regulation of neuron differentiation
          • FGF-2 functions in the control of neuronal cell differentiation but is not essential for proliferation [10]
      • Receptor: 5-HT-1D

      • Receptor: 5-HT-2C

      • Receptor: NPSR1

      Reference