Details for anatomical structure: thymic epithelial cell
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- Related structures
- Hormones
- Receptors
-
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- Related structures
- Hormones
- Receptors
-
Click to access the toolbox
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Synonyms
thymic epithelial cell, ,Links to other resources
Cytomer | cy0052340 |
Related structures
Larger structures
Substructures
Secreted hormones
-
Hormone: Thymulin
- Thymulin production and secretion is strongly influenced by the neuroendocrine system. [1]
Influenced by:
- PRLR in thymic_epithelial_cell
- FTS receptor
in
thymic_epithelial_cell
- Thymulin exerts a controlling feedback effect on its own secretion both in vivo and in vitro. Synthesis of this hormone can be down-regulated by the hormone itself. [3]
- growth hormone receptor
in
thymic_epithelial_cell
- In vitro, human GH can stimulate thymulin release from TEC lines. [4]
- It is likely that these effects of GH are mediated, at least in part, by insulin-like growth factor 1 (IGF-1) as suggested by the fact that the GH-induced enhancement of thymulin production could be prevented by previous treatment with antibodies against IGF-1 or IGF-1 receptor. [4]
- thyroid hormone receptor in thymic_epithelial_cell
- ACTH receptor
in
thymic_epithelial_cell
- Although there are no studies documenting a direct effect of gonadotropins or adrenocorticotropic hormone (ACTH) on thymulin secretion gonadectomy or adrenalectomy in mice is known to induce a transient decrease in serum thymulin levels. This effect is potentiated by the simultaneous removal of the adrenals and gonads. [8]
- In TEC cultures it was shown that exposure to physiological levels of glucocorticoids or gonadal steroids enhanced thymulin concentration in the cell supernatants. [9]
-
Hormone: LFA-3
- In vitro studies suggest that intrathymic T-cell activation is mediated through binding between CD2 receptor on the thymocyte surface and LFA-3 expressed on thymic epithelium, particulary in the thymic subcapsular cortex. [10]
Receptors
-
Receptor: PRLR
- TEC possess PRL receptors. [11]
Influences:
-
Receptor: FTS receptor
Influences:
-
Receptor: growth hormone receptor
- TEC lines are known to possess specific receptors for GH. [12]
Influences:
- Thymulin
- In vitro, human GH can stimulate thymulin release from TEC lines. [4]
- It is likely that these effects of GH are mediated, at least in part, by insulin-like growth factor 1 (IGF-1) as suggested by the fact that the GH-induced enhancement of thymulin production could be prevented by previous treatment with antibodies against IGF-1 or IGF-1 receptor. [4]
-
Receptor: thyroid hormone receptor
Influences:
-
Receptor: ACTH receptor
Influences:
- Thymulin
- Although there are no studies documenting a direct effect of gonadotropins or adrenocorticotropic hormone (ACTH) on thymulin secretion gonadectomy or adrenalectomy in mice is known to induce a transient decrease in serum thymulin levels. This effect is potentiated by the simultaneous removal of the adrenals and gonads. [8]
- In TEC cultures it was shown that exposure to physiological levels of glucocorticoids or gonadal steroids enhanced thymulin concentration in the cell supernatants. [9]
- Thymulin