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Details for anatomical structure: thymic epithelial cell

EndoNet ID: ENC00528

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Synonyms

thymic epithelial cell, ,

Links to other resources

Cytomer cy0052340

Larger structures

    Substructures

      Secreted hormones

      • Hormone: Thymulin

        • Thymulin production and secretion is strongly influenced by the neuroendocrine system. [1]

        Influenced by:

        • PRLR
          in thymic_epithelial_cell
          • Prolactin augments the production of a thymic hormone, thymulin. [2]
          • PRL can stimulate thymulin synthesis and secretion both in vitro and in vivo. [2]
        • FTS receptor
          in thymic_epithelial_cell
          • Thymulin exerts a controlling feedback effect on its own secretion both in vivo and in vitro. Synthesis of this hormone can be down-regulated by the hormone itself. [3]
        • growth hormone receptor
          in thymic_epithelial_cell
          • In vitro, human GH can stimulate thymulin release from TEC lines. [4]
          • It is likely that these effects of GH are mediated, at least in part, by insulin-like growth factor 1 (IGF-1) as suggested by the fact that the GH-induced enhancement of thymulin production could be prevented by previous treatment with antibodies against IGF-1 or IGF-1 receptor. [4]
        • thyroid hormone receptor
          in thymic_epithelial_cell
          • The thyroid axis also influences thymulin secretion. Thus, T4 has been shown to stimulate thymulin synthesis and secretion in mice. [5]
          • In vivo treatment of mice with triiodothyronine enhanced thymulin secretion. [6]
          • Thyroid hormones stimulate thymulin secretion by a direct action on TEC. [7]
        • ACTH receptor
          in thymic_epithelial_cell
          • Although there are no studies documenting a direct effect of gonadotropins or adrenocorticotropic hormone (ACTH) on thymulin secretion gonadectomy or adrenalectomy in mice is known to induce a transient decrease in serum thymulin levels. This effect is potentiated by the simultaneous removal of the adrenals and gonads. [8]
          • In TEC cultures it was shown that exposure to physiological levels of glucocorticoids or gonadal steroids enhanced thymulin concentration in the cell supernatants. [9]

      • Hormone: LFA-3

        • In vitro studies suggest that intrathymic T-cell activation is mediated through binding between CD2 receptor on the thymocyte surface and LFA-3 expressed on thymic epithelium, particulary in the thymic subcapsular cortex. [10]

      Receptors

      • Receptor: PRLR

        • TEC possess PRL receptors. [11]

        Influences:

        • Thymulin
          • Prolactin augments the production of a thymic hormone, thymulin. [2]
          • PRL can stimulate thymulin synthesis and secretion both in vitro and in vivo. [2]

      • Receptor: FTS receptor

        Influences:

        • Thymulin
          • Thymulin exerts a controlling feedback effect on its own secretion both in vivo and in vitro. Synthesis of this hormone can be down-regulated by the hormone itself. [3]

      • Receptor: growth hormone receptor

        • TEC lines are known to possess specific receptors for GH. [12]

        Influences:

        • Thymulin
          • In vitro, human GH can stimulate thymulin release from TEC lines. [4]
          • It is likely that these effects of GH are mediated, at least in part, by insulin-like growth factor 1 (IGF-1) as suggested by the fact that the GH-induced enhancement of thymulin production could be prevented by previous treatment with antibodies against IGF-1 or IGF-1 receptor. [4]

      • Receptor: thyroid hormone receptor

        Influences:

        • Thymulin
          • The thyroid axis also influences thymulin secretion. Thus, T4 has been shown to stimulate thymulin synthesis and secretion in mice. [5]
          • In vivo treatment of mice with triiodothyronine enhanced thymulin secretion. [6]
          • Thyroid hormones stimulate thymulin secretion by a direct action on TEC. [7]

      • Receptor: ACTH receptor

        Influences:

        • Thymulin
          • Although there are no studies documenting a direct effect of gonadotropins or adrenocorticotropic hormone (ACTH) on thymulin secretion gonadectomy or adrenalectomy in mice is known to induce a transient decrease in serum thymulin levels. This effect is potentiated by the simultaneous removal of the adrenals and gonads. [8]
          • In TEC cultures it was shown that exposure to physiological levels of glucocorticoids or gonadal steroids enhanced thymulin concentration in the cell supernatants. [9]
      Reference